5-Amino-1MQMetabolic Small MoleculeSafety Rating 6/10

TypeSmall molecule NNMT inhibitor
CAS42464-96-0
MW159.21 g/mol (cation) / 286.11 g/mol (iodide salt)
Primary research areaLipolysis / metabolic research

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose range50–150 mg oral daily. Research compound; no established clinical dosing. Often cycled.
AdministrationOral
Safety6/10 · Not FDA-approved
NCAA D1Not listed

Price Comparison

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VendorPrice$ / mgUpdated
Puratek PeptidesBest $/mgCOA ✓ · 3POut of stock$49.46$54.95−10% · code PEPTIDEPRICES$0.99May 19, 2026Buy →
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Overview

About 5-Amino-1MQ

Mechanism of action

Selective NNMT (Nicotinamide N-methyltransferase) inhibitor; blocks NNMT from methylating NAD+ precursors; increases NAD+/NADH ratio; activates SIRT1; promotes fat cell 'browning'.

Safety profile

Research compound with limited human data. Theoretical: NAD+ metabolism disruption, GI discomfort. Generally reported as well-tolerated. · Experimental NNMT inhibitor; animal data favorable; no major safety signals identified; WADA banned

Storage

Stability & handling

❄️Lyophilized (powder)−20°Cstable 24+ months
💉Reconstituted2–8°C7–14 days
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Research

Studies & key findings

  • Small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor that raises NAD+ precursor availability in adipose tissue, activating thermogenesis without caloric restriction.
  • Reverses high-fat-diet-induced obesity in mice over 11 weeks, reducing fat mass and improving metabolic markers — results replicated across independent labs.

8 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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