Price Comparison
AICAR
longevity
3 of 3 vendors
| Vendor | Price | 10mg cost | Updated | Actions |
|---|---|---|---|---|
| Nationwide Peptides 6/10 COA ✓Ships: USCredit/debit card Verification & shipping6/10 COA ✓Ships: USCredit/debit card | $43.20 | $43.20Checked aug 5, 2026 | Aug 5, 2026 | Buy AICAR from Nationwide Peptides |
| Peptide Giants 9/10 COA ✓Ships: USCredit/debit card Verification & shipping9/10 COA ✓Ships: USCredit/debit card | $53.99 | $53.99Checked aug 1, 2026 | Aug 1, 2026 | Buy AICAR from Peptide Giants |
| CertaPeptides 7.5/10 COA ✓Ships: InternationalPayment not verified Verification & shipping7.5/10 COA ✓Ships: InternationalPayment not verified | $54.6750mg package | $54.67Checked jun 27, 2026 | Jun 27, 2026 | Buy AICAR from CertaPeptides |
Research details
AICAR — research data
Overview
About AICAR
Mechanism of action
AMP-kinase (AMPK) activator; mimics energy-depletion state; stimulates mitochondrial biogenesis, fatty acid oxidation, and glucose uptake; upregulates PGC-1α; exercise mimetic.
Safety profile
Generally well-tolerated in research. Potential: hypoglycemia, uric acid changes, GI discomfort. Long-term human data limited. · Used in cardiac surgery trials; well-tolerated at clinical doses; hyperuricemia at high doses; WADA banned
Related pages
More on AICAR
Research
Studies & key findings
- Narkar et al. (Cell, 2008) demonstrated that 4 weeks of AICAR in sedentary mice enhanced treadmill running endurance by 44% and upregulated oxidative metabolism genes in skeletal muscle without any exercise — establishing AICAR as the prototypical 'exercise in a pill' and leading to its addition to WADA's prohibited list.
- AICAR activates AMPK by mimicking AMP, triggering downstream phosphorylation of ACC and PGC-1α activation, which drives mitochondrial biogenesis, fatty acid oxidation, and slow-twitch (type I) fiber specification; however, systematic review evidence confirms that numerous AICAR effects are AMPK-independent, including some NF-κB suppression in human macrophages.