AICARAnti-AgingSafety Rating 6/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
Compare vendors · per 50mg
| Vendor | Price | $ / mg | Updated | |
|---|---|---|---|---|
| Pantheon PeptidesBest $/mgCOA ✓ · 3P | $42.12 | $0.84 | Apr 23, 2026 | Buy → |
| Modern AminosCOA ✓ · 3P | $54.00 | $1.08 | May 14, 2026 | Buy → |
| Behemoth LabzCOA ✓ · 3P | $55.96 | $1.12 | May 14, 2026 | Buy → |
| Biotech PeptidesCOA unknown | $56.00 | $1.12 | May 14, 2026 | Buy → |
| PeptiraCOA ✓ · 3P | $59.00 | $1.18 | May 14, 2026 | Buy → |
Overview
About AICAR
Mechanism of action
AMP-kinase (AMPK) activator; mimics energy-depletion state; stimulates mitochondrial biogenesis, fatty acid oxidation, and glucose uptake; upregulates PGC-1α; exercise mimetic.
Safety profile
Generally well-tolerated in research. Potential: hypoglycemia, uric acid changes, GI discomfort. Long-term human data limited. · Used in cardiac surgery trials; well-tolerated at clinical doses; hyperuricemia at high doses; WADA banned
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Related pages
More on AICAR
Research
Studies & key findings
- Narkar et al. (Cell, 2008) demonstrated that 4 weeks of AICAR in sedentary mice enhanced treadmill running endurance by 44% and upregulated oxidative metabolism genes in skeletal muscle without any exercise — establishing AICAR as the prototypical 'exercise in a pill' and leading to its addition to WADA's prohibited list.
- AICAR activates AMPK by mimicking AMP, triggering downstream phosphorylation of ACC and PGC-1α activation, which drives mitochondrial biogenesis, fatty acid oxidation, and slow-twitch (type I) fiber specification; however, systematic review evidence confirms that numerous AICAR effects are AMPK-independent, including some NF-κB suppression in human macrophages.