PeptidePrices safety rating
6/10 · Not FDA-approved
AICAR Prices
13 vendors · 9 with an issuer-verified COA · lowest 10mg from $23.39 · checked
Where to buy AICAR: 13 vendors compared
| Vendor | Price | Actions |
|---|---|---|
| 5-test panelVerified COAILS Laboratories · Tested Jun 28, 2026 | $23.39 | Buy AICAR from Studz Peptides |
| 1-test panelVerified COAJanoshik | $24.25 | Buy AICAR from CertaPeptides |
| 3-test panelVerified COAVanguard Laboratory · Tested Aug 1, 2026 | $35.10 | Buy AICAR from Peptide Giants |
| 1-test panelVerified COAJanoshik · Tested Jul 15, 2026 | $35.99 | Buy AICAR from ZestyRat Research |
| 3-test panelVerified COAFreedom Diagnostics | $36.00 | Buy AICAR from Novaglo Research |
| 2-test panelVerified COAOptima Labs | $39.9950mg packageChecked today | Buy AICAR from Peptides Lab UK |
| Verified COAChromate | $42.12 | Buy AICAR from Pantheon Peptides |
| 1-test panelVerified COAJanoshik · Tested Apr 9, 2026 | $44.8150mg packageChecked today | Buy AICAR from Omega Peptides |
| 6-test panelVerified COABioSyn Systems · Tested Oct 20, 2025 | $51.99 | Buy AICAR from Cenexa Labs |
| $52.20 | Buy AICAR from Nationwide Peptides | |
| $55.0050mg packageChecked today | Buy AICAR from Alpha Carbon Labs | |
| $80.36 | Buy AICAR from Atlas Longevity | |
| $85.50 | Buy AICAR from Peptides Costa Rica |
Tracked every day
AICAR listing prices, tracked daily
The five cheapest in-stock package prices for AICAR on each collected day, and the vendors that most often held those places.
Five cheapest in-stock package prices per day
Listed package price before coupons, any vial size. This is not the coupon-adjusted lowest 10mg price used to rank the comparison.
- Cheapest$25.99
- 2nd cheapest$39.00
- 3rd cheapest$39.99
- 4th cheapest$40.00
- 5th cheapest$44.81
Vendors most often in the cheapest five
- Peptide Giants22 days$39.000.0%
- Alpha Carbon Labs18 days$55.00last seen Oct 7, 20260.0%
- Nationwide Peptides17 days$56.00last seen Oct 7, 2026-1.8%
- Pantheon Peptides15 days$46.80last seen Oct 9, 20260.0%
- Studz Peptides5 days$25.990.0%
- Cenexa Labs5 days$64.99last seen Oct 6, 20260.0%
- Novaglo Research4 days$40.000.0%
- Omega Peptides3 days$44.81+0.2%
Top 8 of 10 vendors that reached the cheapest five
Current market data
AICAR Price Report
A current summary of public listings after the price comparison above. Shipping and tax are not included.
The lowest current 10mg cost for AICAR is $23.39 from Studz Peptides. The median across vendors is $42.12.
- Lowest 10mg cost
- $23.39Studz Peptides
- Median 10mg cost
- $42.12One normalized offer per vendor
- Lowest package total
- $23.39Studz Peptides · package size may differ
- Public COA coverage
- 100%13 of 13 vendors
What the market shows
PeptidePrices found 13 in-stock listings from 13 vendors, checked through Oct 10, 2026. The lowest 10mg cost is 44% below the vendor median of $42.12; 6 vendors (46%) fall below that median. 13 of 13 vendors (100%) publish public COA evidence.
A public COA link shows that a vendor publishes testing data. It does not prove that every listed vial has a matching current report. Match the product, strength, batch, and lot before relying on a report.
How this report is calculated
The headline and median use each vendor's lowest whole-package checkout cost to obtain at least 10mg. Smaller packages are multiplied until the target is met, while larger packages retain their full checkout price. The lowest package total is shown only as secondary context because package sizes differ. Known public coupon discounts are applied. Shipping, tax, and unverified promotions are excluded.
Research context
What is AICAR? Research, safety, and status
AICAR at a glance
Mechanism
AMP-kinase (AMPK) activator; mimics energy-depletion state; stimulates mitochondrial biogenesis, fatty acid oxidation, and glucose uptake; upregulates PGC-1α; exercise mimetic.
Research areas
Endurance enhancement; fat burning; metabolic health; exercise mimetic; AMPK activation; insulin sensitizer; cardiovascular protection.
Regulatory / research status
Research / preclinical only
Half-life
~1-2 hours.
Storage
Lyophilized vial: store at -20°C long-term or 2-8°C short-term, protected from light.
Reported side effects
Generally well-tolerated in research. Potential: hypoglycemia, uric acid changes, GI discomfort. Long-term human data limited.
Used in cardiac surgery trials; well-tolerated at clinical doses; hyperuricemia at high doses; WADA banned Safety ratings summarize published clinical data, adverse-event reporting, and regulatory status. How PeptidePrices rates evidence. Research information only, not medical advice.
Study highlights
- Narkar et al. (Cell, 2008) demonstrated that 4 weeks of AICAR in sedentary mice enhanced treadmill running endurance by 44% and upregulated oxidative metabolism genes in skeletal muscle without any exercise, establishing AICAR as the prototypical 'exercise in a pill' and leading to its addition to WADA's prohibited list.
- AICAR activates AMPK by mimicking AMP, triggering downstream phosphorylation of ACC and PGC-1α activation, which drives mitochondrial biogenesis, fatty acid oxidation, and slow-twitch (type I) fiber specification; however, systematic review evidence confirms that numerous AICAR effects are AMPK-independent, including some NF-κB suppression in human macrophages.
- AICAR inhibits NF-κB DNA binding independently of AMPK in primary human macrophages, reducing LPS-induced pro-inflammatory gene expression, a distinct anti-inflammatory pathway relevant to insulin resistance and metabolic syndrome where chronic low-grade inflammation is a driver.
- Prior AICAR stimulation in mouse skeletal muscle enhances subsequent insulin-stimulated glucose uptake in an AMPK-dependent manner via TBC1D4 phosphorylation; IV AICAR has also been shown to reduce hepatic glucose output in human type 2 diabetic patients, providing limited but real clinical pharmacological data.
Selected references
- AMPK and PPARdelta Agonists Are Exercise Mimetics · Cell, 2008
- AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review · Cells / PMC, 2021
- AICAR Inhibits NF-κB DNA Binding Independently of AMPK to Attenuate LPS-Triggered Inflammatory Responses in Human Macrophages · Sci Rep, 2018
- Prior AICAR Stimulation Increases Insulin Sensitivity in Mouse Skeletal Muscle in an AMPK-Dependent Manner · PubMed, 2015
- AMPK Agonist AICAR Improves Cognition and Motor Coordination in Young and Aged Mice · PMC, 2014
- AMP-Activated Protein Kinase, An Energy Sensor That Regulates All Aspects of Cell Function · Genes Dev, 2011
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