MOTS-cMetabolic PeptideSafety Rating 7/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
Compare vendors · per 10mg
| Vendor | Price | $ / mg | Updated | |
|---|---|---|---|---|
| Puratek PeptidesBest $/mgCOA ✓ · 3POut of stock | $62.96 | $1.57 | May 19, 2026 | Buy → |
| Red River PeptidesCOA ✓ · 3PAvailable on backorder | $63.75 | $1.59 | May 19, 2026 | Buy → |
| Puratek PeptidesCOA ✓ · 3P | $26.95 | $2.70 | May 19, 2026 | Buy → |
| Petratide ScienceCOA ✓ · 3P | $29.95 | $3.00 | May 14, 2026 | Buy → |
| Ascension PeptidesCOA ✓ · 3P | $30.00 | $3.00 | Apr 16, 2026 | Buy → |
Overview
About MOTS-c
Mechanism of action
Mitochondria-derived peptide encoded in the 12S rRNA gene; activates AMPK; improves insulin sensitivity; enhances mitochondrial biogenesis; regulates folate cycle and purine metabolism.
Safety profile
Generally well-tolerated in early research. Possible fatigue, injection site reactions. Long-term human data limited. · Endogenous mitochondrial peptide; human study showed safety in metabolic syndrome; promising early data
Storage
Stability & handling
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Safety & Interactions
Contraindications & Drug Interactions
Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.
Limited human clinical data; long-term safety unknown.
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MOTS-c Guide
The mitochondrial peptide being studied for metabolic and exercise performance.
Read full guide · 8 min read →Research
Studies & key findings
- Mitochondrial-derived peptide encoded in the 12S rRNA gene; regulates nuclear gene expression from the mitochondria — a paradigm-shifting finding in organelle-to-nucleus communication.
- Exercise-inducible: serum MOTS-c rises after physical activity and mediates improvements in insulin sensitivity and metabolic homeostasis via AMPK activation.