SLU-PP-332EnduranceSafety Rating 6/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
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| Vendor | Price | $ / mg | Updated | |
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| SomaChemsBest $/mgCOA ✓ · 3P | $59.99 | $6.67 | May 14, 2026 | Buy → |
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Overview
About SLU-PP-332
Mechanism of action
Potent synthetic agonist of estrogen-related receptors α, β, and γ (ERRα/β/γ); activates mitochondrial biogenesis; enhances oxidative metabolism in muscle; mimics exercise adaptations.
Safety profile
Insufficient human data. Theoretical: hormonal disruption (ERR signaling), cardiovascular effects. Promising safety in animal studies. · Early research compound; novel mechanism; no proven harms; animal data shows exercise-mimetic effects
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Related pages
More on SLU-PP-332
Research
Studies & key findings
- SLU-PP-332 is a first-in-class synthetic pan-ERR agonist (ERRα EC50 = 98 nM, ERRβ 230 nM, ERRγ 430 nM) developed at Saint Louis University; in mice, 28-day administration increased type IIa oxidative skeletal muscle fibers and boosted treadmill endurance by ~70% in distance and ~45% in duration — effects shown to be ERRα-dependent via muscle-specific knockout validation.
- Mechanistically, SLU-PP-332 stabilizes the ERRα active conformation and recruits PGC-1α, inducing a transcriptional program overlapping with acute aerobic exercise — particularly upregulating mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation genes without requiring physical activity.