AOD-9604Cellular PeptideSafety Rating 8/10

TypeModified peptide fragment
MW~1,815 g/mol
AAs15 (modified)
Primary research areaLipolysis research

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose range250 mcg–1 mg SC daily (historical Phase 2 protocol)source ↗
AdministrationSubcutaneous injection (abdomen)
Half-life~30 minutes (parent fragment)
Safety8/10 · Not FDA-approved (GRAS in AU)
NCAA D1Banned

Price Comparison

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Overview

About AOD-9604

Mechanism of action

Modified fragment of HGH C-terminus (177–191). Stimulates lipolysis and inhibits lipogenesis via beta-3 adrenergic receptors without affecting IGF-1 or blood glucose.

Safety profile

Injection site reactions, headache, redness at injection site. No insulin resistance. Generally very safe. · 6+ RCTs, 900+ participants; no IGF-1 or glucose effects; excellent tolerability; GRAS status in Australia

Storage

Stability & handling

❄️Lyophilized (powder)−20°Cstable 2+ years
💉Reconstituted2–8°Cwithin 30 days
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Research

Studies & key findings

  • Fragment of the C-terminal region of human GH (amino acids 177–191) that retains lipolytic activity without stimulating IGF-1 production, avoiding growth-promoting side effects.
  • Phase IIa 12-week trial (1 mg/day oral, n~300) showed a 2.6 kg weight loss vs 0.8 kg with placebo — but the larger 24-week Phase IIb OPTIONS trial (n=536) failed to meet its primary endpoint, and Metabolic Pharmaceuticals terminated obesity development in March 2007.

6 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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