SS-31 Prices

129 vendors · 74 with an issuer-verified COA · lowest 10mg from $20.00 · checked

Where to buy SS-31: 129 vendors compared

Showing 6 of 129 vendors
Prices for SS-31 by vendor
VendorPriceActions
6-test panelVerified COAKovera Labs · Tested May 28, 2026$20.0010mg packageChecked todayBuy SS-31 from Renova Peptides
3-test panelVerified COAFreedom Diagnostics$20.76$24.42−15% · code peptideprices10mg packageChecked todayBuy SS-31 from Hacker Peptides
5-test panelVerified COAFreedom Diagnostics · Tested Jun 8, 2026$22.99$30.65−25% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Modern Research Peptides
6-test panelVerified COAFreedom Diagnostics · Tested Apr 7, 2026$24.25$29.25$5.00 off · code peptideprices10mg packageChecked Sep 6Buy SS-31 from Rocky Mountain Compounds
5-test panelVerified COAKovera Labs · Tested May 28, 2026$25.65$27.00−5% · code peptideprices10mg packageChecked todayBuy SS-31 from RetaOne Labs
5-test panelVerified COAFreedom Diagnostics · Tested Aug 4, 2026$27.00$30.00−10% · code peptideprices10mg packageChecked Aug 1Buy SS-31 from TrustedPeps
4-test panelVerified COAKovera Labs · Tested Sep 17, 2026$27.90$31.00−10% · code JINAVWGXN010mg packageChecked todayBuy SS-31 from Vector Amino Labs
4-test panelVerified COAKovera Labs · Tested Aug 12, 2026$28.8010mg packageChecked todayBuy SS-31 from Real Peptides
7-test panelVerified COAKovera Labs · Tested Aug 17, 2026$31.49$34.99−10% · code PEPTIDEP10mg packageChecked todayBuy SS-31 from IDUN Peptides
5-test panelVerified COAKovera Labs · Tested May 28, 2026$31.50$35.00−10% · code peptideprices10mg packageChecked todayBuy SS-31 from Lost Coast Aminos
3-test panelVerified COABioViridian$31.50$35.00−10% · code PEPTIDEPRICES10mg packageChecked Oct 5Buy SS-31 from P3 Labs
$32.40$36.00−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Ararat Peptides
3-test panelVerified COAFreedom Diagnostics · Tested Jul 15, 2026$33.99$42.49−20% · code peptideprices10mg packageChecked todayBuy SS-31 from Everest Peptides
2-test panelCOA on fileVanguard Laboratory$35.10$39.00−10% · code PP1010mg packageChecked todayBuy SS-31 from Noble Sciences
$35.27$44.09−20% · code peptideprices10mg packageChecked todayBuy SS-31 from T-Core Biotech
2-test panelVerified COAJanoshik · Tested Sep 25, 2026$35.6410mg packageChecked todayBuy SS-31 from Corix Labs
3-test panelVerified COAFreedom Diagnostics · Tested Sep 21, 2026$35.99$39.99−10% · code peptideprices10mg packageChecked Oct 2Buy SS-31 from HLX Labs
4-test panelVerified COAFreedom Diagnostics · Tested Jul 15, 2026$35.99$39.99−10% · code peptideprices10mg packageChecked Aug 19Buy SS-31 from MS Peptides
4-test panelVerified COAJanoshik · Tested Jul 22, 2026$36.00$40.00−10%10mg packageChecked todayBuy SS-31 from Giga Compounds
4-test panelVerified COAILS Laboratories · Tested Aug 7, 2026$36.00$40.00−10% · code peptideprices1010mg packageChecked todayBuy SS-31 from RNX Research
3-test panelVerified COASideChain Analytics · Tested Sep 27, 2026$36.00$40.00−10% · code peptideprices10mg packageChecked Sep 25Buy SS-31 from Volta Peptides
3-test panelVerified COAFreedom Diagnostics · Tested Sep 9, 2025$37.58$41.76−10% · code PEPTIDEPRICES1010mg packageChecked Oct 2Buy SS-31 from Alpha Peptides
3-test panelCOA on fileJanoshik · Tested Jun 19, 2026 · Client sales@molipeptide.com$37.67$41.86−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from PhaseOne AUS
4-test panelVerified COAILS Laboratories · Tested Jul 28, 2026$38.25$45.00−15% · code PEPTIDEPRICES1510mg packageChecked todayBuy SS-31 from Peptide Maxxing
3-test panelVerified COAFreedom Diagnostics · Tested May 28, 2026$39.90$42.00−5% · code peptideprices10mg packageChecked todayBuy SS-31 from Endura Peptides
5-test panelVerified COAKovera Labs · Tested May 26, 2026$39.99$79.99−50% · code PEPTIDEPRICES5010mg packageChecked todayBuy SS-31 from Ascension Peptides
$40.0010mg packageChecked Aug 1Buy SS-31 from PeakForm Peptides
$40.0910mg packageChecked todayBuy SS-31 from Pure Peptides UK
4-test panelVerified COAFreedom Diagnostics$40.46$44.95−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Instant Peptides
5-test panelCOA on fileAverix Laboratories (in-house) · Tested Mar 14, 2026$40.49$44.99−10% · code PEPTIDEPRICES10mg packageChecked Sep 25Buy SS-31 from Averix Labs
6-test panelVerified COAProof Point Analytical · Tested Sep 22, 2026$40.49$44.99−10% · code PEPTIDEP1010mg packageChecked todayBuy SS-31 from Prism Labs
3-test panelVerified COAKovera Labs · Tested Sep 1, 2026$40.49$44.99−10% · code supportpeptideprices-net1010mg packageChecked todayBuy SS-31 from Thrive Peptides
4-test panelVerified COAFreedom Diagnostics$40.50$45.00−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Novaglo Research
7-test panelVerified COAEthos Analytics · Tested Jul 27, 2026$41.39$45.99−10% · code peptidep10mg packageChecked todayBuy SS-31 from Glacier Aminos
Verified COAFreedom Diagnostics$42.12$46.80−10% · code PEPTIDEPRICES1010mg packageChecked todayBuy SS-31 from Pantheon Peptides
5-test panelVerified COAILS Laboratories · Tested May 8, 2026$42.49$49.99−15% · code peptideprices10mg packageChecked todayBuy SS-31 from Voltera Sciences
7-test panelVerified COAILS Laboratories · Tested Sep 4, 2026$42.74$44.99−5% · code peptideprices10mg packageChecked todayBuy SS-31 from ZC Labs
$43.20$48.00−10% · code peptideprices10mg packageChecked todayBuy SS-31 from Ascend Amino
3-test panelVerified COAFreedom Diagnostics · Tested Mar 24, 2026$43.20$48.00−10% · code peptideprices10mg packageChecked todayBuy SS-31 from Athena Peptides
3-test panelVerified COAFreedom Diagnostics$43.20$48.00−10% · code peptideprices10mg packageChecked todayBuy SS-31 from Nationwide Peptides
3-test panelVerified COASideChain Analytics$43.43$48.25−10% · code PEPTIDEPRICES10mg packageChecked Oct 3Buy SS-31 from Vistara Labs
$44.1610mg packageChecked todayBuy SS-31 from Optic Labs AU
$44.69$49.66−10% · code peptideprices10mg packageChecked todayBuy SS-31 from NexPept
$44.99$49.99−10% · code johnryan10mg packageChecked todayBuy SS-31 from Peptide Giants
$44.99$49.99−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Refined BioLabs
$44.9910mg packageChecked Oct 5Buy SS-31 from Vortex Research
$45.00$50.00−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from American Amino & Peptides
$45.68$52.50−13% · code peptideprices10mg packageChecked todayBuy SS-31 from Panda Peptide
$46.74$54.99−15% · code PEPTIDEPRICES10mg packageChecked Aug 1Buy SS-31 from Purgo Labs
3-test panelVerified COAFreedom Diagnostics · Tested Jul 23, 2025$46.74$54.99−15% · code PEPTIDEPRICES10mg packageChecked May 14Buy SS-31 from SomaChems
$46.75$55.00−15% · code peptideprices10mg packageChecked todayBuy SS-31 from Impact Aminos
3-test panelVerified COAFreedom Diagnostics · Tested Jul 22, 2026$47.20$59.00−20% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Kyreon
5-test panelVerified COABioViridian$47.60$56.00−15% · code PEPTIDEPRI1510mg packageChecked todayBuy SS-31 from PeakForce Labs
2-test panelVerified COAJanoshik$48.48$53.87−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from CertaPeptides
7-test panelVerified COAKovera Labs · Tested May 20, 2026$49.29$57.99−15% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Synthesis Peptides
4-test panelVerified COAMDx BioAnalytical · Tested Apr 23, 2026$49.30$58.00−15% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Happy Peptides
3-test panelVerified COAFreedom Diagnostics$49.50$55.00−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Axon Chems
$49.50$55.00−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Peptide Express
3-test panelVerified COABT Labs · Tested Aug 26, 2026$50.15$59.00−15% · code peptideprices1510mg packageChecked todayBuy SS-31 from Alpine Peptide
3-test panelVerified COAFreedom Diagnostics · Tested Sep 2, 2026$50.39$55.99−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Rebirth Labs
3-test panelVerified COAFreedom Diagnostics$50.99$59.99−15% · code supportpeptideprices-net1510mg packageChecked Sep 29Buy SS-31 from Rivn Peptides
$51.00$60.00−15% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Evolve Peptides
$53.0010mg packageChecked todayBuy SS-31 from Apex Compounds
3-test panelVerified COAFreedom Diagnostics$53.09$58.99−10% · code pep1010mg packageChecked todayBuy SS-31 from GMR Peptides
3-test panelVerified COAKovera Labs · Tested Sep 29, 2026$53.10$59.00−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from LabFirst Peptides
$53.99$59.99−10% · code PEPTIDEPRICES10mg packageChecked Jun 18Buy SS-31 from Midwest Peptide
$53.99$59.99−10% · code PEPTIDEPRICES10mg packageChecked Oct 3Buy SS-31 from Prime Peptide Solutions
3-test panelCOA on fileAccurate Test Labs · Tested Sep 3, 2026$54.00$60.00−10% · code PEPTIDEPRICES10mg packageChecked Sep 24Buy SS-31 from Eon Peptides
$54.0010mg packageChecked todayBuy SS-31 from True Research Labs
$55.99$69.99−20% · code PEPTIDEPRICES10mg packageChecked Jun 22Buy SS-31 from Evo Labs Research
3-test panelVerified COAFreedom Diagnostics · Tested May 23, 2026$56.00$70.00−20% · code peptideprices10mg packageChecked todayBuy SS-31 from VAYN
3-test panelVerified COAFreedom Diagnostics · Tested Aug 30, 2026$56.09$65.99−15% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from HEEZ Research
$57.78$64.20−10% · code PEPTIDEPRICES10mg packageChecked Aug 7Buy SS-31 from Durham Peptides
3-test panelVerified COAKovera Labs · Tested Jul 30, 2026$58.0010mg packageChecked todayBuy SS-31 from Pure Peptides
4-test panelVerified COANorth American Diagnostics · Tested Jun 15, 2026$58.49$64.99−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from PS Peptides
$58.65$69.00−15% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Apex Peptides Lab
$59.96$74.95−20% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from ORA Labs
5-test panelVerified COAILS Laboratories$59.9910mg packageChecked todayBuy SS-31 from Northline Labs
7-test panelVerified COAKovera Labs$60.41$67.12−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from NeuroLabs
5-test panelVerified COAFreedom Diagnostics · Tested Jun 18, 2026$62.99$69.99−10% · code PEPTIDEP1010mg packageChecked todayBuy SS-31 from SKO Compounds
3-test panelVerified COABioViridian$63.00$70.00−10% · code JOHN10569910mg packageChecked todayBuy SS-31 from American Peptides
2-test panelVerified COAHorizon Analytical$63.00$70.00−10% · code PEPTIDEPRICES10mg packageChecked Sep 30Buy SS-31 from Blank Peptides
$63.19$78.99−20% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from Amino Science Labs
$63.75$75.00−15% · code SL5MSNFF10mg packageChecked Aug 26Buy SS-31 from Sparta Labs
$65.47$72.74−10% · code JACKRYAN1010mg packageChecked todayBuy SS-31 from Atlas Longevity
3-test panelVerified COAFreedom Diagnostics$65.9910mg packageChecked todayBuy SS-31 from Alpha Pro Peptides
$66.8410mg packageChecked todayBuy SS-31 from Kensington Labs
5-test panelVerified COAILS Laboratories$67.46$74.95−10% · code PEPTIDEPRICES30mg packageChecked Oct 5Buy SS-31 from Puratek Peptides
3-test panelVerified COAFreedom Diagnostics$67.49$74.99−10% · code PEPTIDEPRICES10mg packageChecked Sep 29Buy SS-31 from Fit Aminos
3-test panelVerified COAKovera Labs · Tested Jul 19, 2026$67.50$75.00−10% · code peptideprices10mg packageChecked todayBuy SS-31 from Peptoria
$67.99$79.99−15% · code PEPTIDEPRICES10mg packageChecked Oct 3Buy SS-31 from Purity Peptides
$67.99$79.99−15% · code PEPTIDEPRICES50mg packageChecked Oct 5Buy SS-31 from Red River Peptides
4-test panelVerified COALiquilabs · Tested Sep 8, 2026$68.1810mg packageChecked Oct 7Buy SS-31 from Adria Science
5-test panelVerified COAILS Laboratories · Tested Sep 4, 2026$68.39$75.99−10% · code PEPTIDEPRICES50mg packageChecked todayBuy SS-31 from Studz Peptides
4-test panelVerified COAILS Laboratories · Tested Jun 30, 2026$69.04$138.07−50% · code peptideprices50mg packageChecked todayBuy SS-31 from Precisely Peptides
$70.0010mg packageChecked Aug 2Buy SS-31 from Pristine Aminos
2-test panelCOA on fileVanguard Laboratory$71.10$79.00−10% · code PP1010mg packageChecked todayBuy SS-31 from AmiNexa
5-test panelVerified COAFreedom Diagnostics · Tested Jun 17, 2026$71.10$79.00−10% · code peptideprices50mg packageChecked todayBuy SS-31 from Step One Ventures
$75.0010mg packageChecked todayBuy SS-31 from Elite RX Labs
2-test panelVerified COATestides · Tested Mar 28, 2026$76.9910mg packageChecked todayBuy SS-31 from Cellugenix Peptides
$80.0010mg packageChecked todayBuy SS-31 from Alpha Carbon Labs
$84.99$99.99−15% · code peptideprices10mg packageChecked todayBuy SS-31 from Orbitrex Peptides
$85.50$95.00−10% · code peptideprices10mg packageChecked todayBuy SS-31 from Upgrade Bio Labs
$87.89$97.65−10% · code PEPTIDEPRICES10mg packageChecked todayBuy SS-31 from BergdorfBio
$88.20$98.00−10% · code peptidep1030mg packageChecked todayBuy SS-31 from Ameano Peptides
Verified COAJanoshik$88.20$98.00−10% · code peptideprices30mg packageChecked todayBuy SS-31 from EZ Peptides
$89.98$99.98−10% · code support102 × 5mg packages · 10mg totalChecked Sep 24Buy SS-31 from ZestyRat Research
4-test panelCOA on fileAxisPharm · Tested Dec 23, 2025$94.99$99.99−5% · code peptideprices510mg packageChecked todayBuy SS-31 from BioPure Peptides
3-test panelVerified COAVanguard Laboratory · Tested Aug 31, 2026$95.3010mg packageChecked todayBuy SS-31 from Nova Biolabs
$99.995% off via our link·auto10mg packageChecked todayBuy SS-31 from Licensed Peptides
4-test panelVerified COAKovera Labs · Tested Sep 4, 2026$101.50$145.00−30% · code PEPTIDEPRICES50mg packageChecked todayBuy SS-31 from Axovera Labs
$105.00$150.00−30% · code PEPTIDEPRICES50mg packageChecked todayBuy SS-31 from Essential Research Labs
$105.2450mg packageChecked todayBuy SS-31 from Pure Peptide
3-test panelVerified COAFreedom Diagnostics · Tested Jun 1, 2026$107.99$119.99−10% · code peptideprices10mg packageChecked todayBuy SS-31 from UNYX Peptides
7-test panelVerified COAILS Laboratories · Tested Sep 2, 2026$110.49$129.99−15% · code PEPTIDEPRICES50mg packageChecked todayBuy SS-31 from EZ Peps
$116.10$129.00−10% · code PEPTIDEPRICES10mg packageChecked Oct 5Buy SS-31 from Nurish Labs
2-test panelVerified COAOptima Labs$131.0410mg packageChecked Sep 20Buy SS-31 from Peptides Lab UK
5-test panelVerified COAJanoshik · Tested Jun 22, 2026$131.25$175.00−25% · code PEPTIDEP2550mg packageChecked todayBuy SS-31 from Hydro Research
$131.99$175.99−25% · code peptideprices2550mg packageChecked todayBuy SS-31 from Swift Peptides
Verified COAFreedom Diagnostics · Tested Mar 20, 2026 · Purity 99.892%$135.00$150.00−10% · code peptideprices50mg packageChecked todayBuy SS-31 from Great Northern Peptides
$135.00$150.00−10% · code PEPTIDEPRICES25mg packageChecked Oct 4Buy SS-31 from Peptides Costa Rica
$140.0050mg packageChecked todayBuy SS-31 from Iaso BioLabs
3-test panelVerified COAJanoshik · Tested Jun 22, 2026$148.75$175.00−15% · code PEPTIDEPRICES50mg packageChecked todayBuy SS-31 from Optima Supply
$149.25$199.00−25% · code peptideprices50mg packageChecked Sep 29Buy SS-31 from Atomik Labz
$152.99$169.99−10% · code PEPTIDEP1050mg packageChecked Jun 21Buy SS-31 from Arizen Bio Labs
4-test panelCOA on fileAPIGENEX$153.2850mg packageChecked todayBuy SS-31 from Particle Peptides
6-test panelVerified COALiquilabs · Tested Sep 16, 2026$156.4750mg packageChecked todayBuy SS-31 from Omega Peptides
$160.3650mg packageChecked todayBuy SS-31 from Regenix Peptides
Verified COAILS Laboratories$177.65$187.00−5% · code MAJ1X21RBB50mg packageChecked todayBuy SS-31 from Amino Vault

Tracked every day

SS-31 listing prices, tracked daily

The five cheapest in-stock package prices for SS-31 on each collected day, and the vendors that most often held those places.

Five cheapest in-stock package prices per day

Listed package price before coupons, any vial size. This is not the coupon-adjusted lowest 10mg price used to rank the comparison.

$39.69$28.79$17.89Sep 20Sep 25Sep 29Oct 4Oct 8
  • Cheapest$20.00
  • 2nd cheapest$27.00
  • 3rd cheapest$28.80
  • 4th cheapest$30.65
  • 5th cheapest$31.00

Vendors most often in the cheapest five

  • RetaOne Labs16 days$27.000.0%
  • Real Peptides14 days$28.800.0%
  • Modern Research Peptides14 days$30.650.0%
  • Lost Coast Aminos13 days$32.00last seen Oct 2, 2026-8.6%
  • IDUN Peptides13 days$34.99last seen Oct 1, 20260.0%
  • Vector Amino Labs7 days$31.000.0%
  • Renova Peptides6 days$20.000.0%
  • P3 Labs5 days$35.00last seen Sep 24, 20260.0%

Top 8 of 11 vendors that reached the cheapest five

Current market data

SS-31 Price Report

A current summary of public listings after the price comparison above. Shipping and tax are not included.

Checked through

The lowest current 10mg cost for SS-31 is $20.00 from Renova Peptides. The median across vendors is $53.10.

Lowest 10mg cost
$20.00Renova Peptides
Median 10mg cost
$53.10One normalized offer per vendor
Lowest package total
$20.00Renova Peptides · package size may differ
Public COA coverage
98%127 of 129 vendors

What the market shows

PeptidePrices found 174 in-stock listings from 129 vendors, checked through Oct 8, 2026. The lowest 10mg cost is 62% below the vendor median of $53.10; 64 vendors (50%) fall below that median. 127 of 129 vendors (98%) publish public COA evidence.

A public COA link shows that a vendor publishes testing data. It does not prove that every listed vial has a matching current report. Match the product, strength, batch, and lot before relying on a report.

How this report is calculated

The headline and median use each vendor's lowest whole-package checkout cost to obtain at least 10mg. Smaller packages are multiplied until the target is met, while larger packages retain their full checkout price. The lowest package total is shown only as secondary context because package sizes differ. Known public coupon discounts are applied. Shipping, tax, and unverified promotions are excluded.

Research context

What is SS-31? Research, safety, and status

SS-31 (Elamipretide) is a first-in-class mitochondria-targeting peptide built to address the root cause of diseases driven by mitochondrial dysfunction, rather than their downstream symptoms. It is a four-amino-acid peptide engineered to selectively accumulate inside mitochondria, where it stabilizes the inner-membrane phospholipid cardiolipin and, with it, the machinery that generates cellular energy.

It stands apart from most peptides discussed in the longevity/performance space in two ways: it acts at the level of cellular bioenergetics (not growth-factor or hormonal pathways), and it has a real clinical-trial record, culminating in FDA accelerated approval in September 2025 (as FORZINITY) for Barth syndrome, the first approved therapy for any mitochondrial disease.

Key research takeaways

SS-31 (Elamipretide; also Bendavia / MTP-131) is a synthetic aromatic-cationic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂) that selectively concentrates in mitochondria, 1,000-5,000× the surrounding cytosol, to protect mitochondrial structure rather than scavenge free radicals after the fact.

Its core mechanism is binding and stabilizing cardiolipin, the inner-membrane phospholipid that scaffolds the electron-transport-chain complexes, preserving ETC architecture, improving ATP output, and cutting reactive-oxygen-species generation at the source.

Landmark fact: on September 19, 2025 the FDA granted accelerated approval to elamipretide (brand FORZINITY) for Barth syndrome in patients ≥30 kg, the FIRST FDA-approved therapy for any mitochondrial disease.

It is approved ONLY for Barth syndrome; for every other indication (heart failure, primary mitochondrial myopathy, age-related decline) it remains investigational, and the largest cardiac trials missed their primary endpoints.

It is NOT currently on the WADA Prohibited List (unlike BPC-157), though the S0 non-approved-substance catch-all could plausibly capture non-Barth use.

SS-31 at a glance

PeptidePrices safety rating

8/10 · FDA-approved (Barth Syndrome)

Mechanism

Mitochondria-targeted antioxidant tetrapeptide; localizes to inner mitochondrial membrane; interacts with cardiolipin; reduces ROS; improves mitochondrial electron transport efficiency and ATP production.

Research areas

Mitochondrial disease; heart failure; kidney disease; aging-related mitochondrial dysfunction; ischemia-reperfusion injury; neurodegenerative diseases; exercise performance.

Regulatory / research status

Research / preclinical only

Half-life

~2-3 hours. Daily SC injection.

Storage

Lyophilized vial: store at -20°C long-term or 2-8°C short-term, protected from light.

Reported side effects

Generally well-tolerated in trials. Nausea reported. Long-term human data still emerging.

FDA-approved Sept 2025; 600+ patients in trials; injection site reactions main AE; well-tolerated Safety ratings summarize published clinical data, adverse-event reporting, and regulatory status. How PeptidePrices rates evidence. Research information only, not medical advice.

Study highlights

  • SS-31 selectively binds cardiolipin on the inner mitochondrial membrane, stabilizing cristae architecture and electron transport chain supercomplexes; PNAS proteomics identified 12 direct SS-31 interactors, all cardiolipin-binding proteins involved in OXPHOS and 2-oxoglutarate metabolism.
  • Ex vivo treatment of explanted failing human hearts acutely improved mitochondrial respiration and supercomplex function, demonstrating the mechanism is independent of long-term cardiolipin remodeling (JACC: Basic to Translational Science, 2019).
  • Phase 2a trial in 14 patients with atherosclerotic renal artery stenosis showed that adjunctive elamipretide during stent revascularization reduced renal tissue hypoxia by 6% vs. +47% in placebo and increased renal blood flow from 202 to 262 mL/min, supporting mitochondrial protection during ischemia-reperfusion.
  • The PROGRESS-HF Phase 2 trial (71 patients, HFrEF) found elamipretide well-tolerated but did not significantly improve LVESV at 4 weeks; the TAZPOWER open-label extension (168 weeks) in Barth syndrome demonstrated significant improvements in 6-Minute Walk Test and cardiac stroke volumes, leading to FDA accelerated approval of Forzinity in September 2025.

Selected references

  1. Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial · Journal of Cardiac Failure, 2020
  2. Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide · Circ Heart Fail, 2017
  3. Phase 2a Clinical Trial of Elamipretide During Stent Revascularization in Atherosclerotic Renal Artery Stenosis · Circ Cardiovasc Interv, 2017
  4. Elamipretide Improves Mitochondrial Function in the Failing Human Heart · JACC Basic Transl Sci, 2019
  5. Mitochondrial Protein Interaction Landscape of SS-31 · PNAS, 2020
  6. SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease · PMC, 2022

Related pages

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