TB-500 (Thymosin Beta-4)Cellular PeptideSafety Rating 6/10

TypeEndogenous peptide / synthetic analog
CAS77591-33-4
MW4,963 Da
AAs43
Primary research areaTissue repair research

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose rangeLimited clinical data; research protocols 2–5 mg weekly (loading), then 2 mg/wksource ↗
AdministrationSubcutaneous or intramuscular injection
Half-life~2–3 hours (parent TB4)
Safety6/10 · Not FDA-approved
NCAA D1Banned

Price Comparison

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19 vendors competing

VendorPrice$ / mgUpdated
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Apex Peptide SupplyCOA ✓ · 3P$59.99$6.00May 14, 2026Buy →
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Overview

About TB-500

Mechanism of action

Upregulates actin, promotes cell migration and proliferation, inhibits inflammatory cytokines (IL-6, TNF-α), stimulates angiogenesis and neurogenesis.

Safety profile

Head rush/fatigue immediately post-injection; possible nausea; theoretical concern re: cancer proliferation (avoid with active malignancy). · Parent protein TB4 has Phase II data; fragment widely used anecdotally; proangiogenic concern theoretical

Storage

Stability & handling

❄️Lyophilized (powder)−20°Cstable long-term
💉Reconstituted2–8°C14–30 days
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Safety & Interactions

Contraindications & Drug Interactions

Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.

! CautionCaution

Active malignancy — TB-500 is pro-angiogenic and may theoretically accelerate tumor growth.

ℹ NoteCaution

Pregnancy and lactation — no human safety data.

ℹ NoteInteraction

Frequently stacked with BPC-157 for tissue repair; no clinical evidence of synergy but widely reported anecdotally.

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TB-500 Guide

A complete guide to TB-500 (Thymosin Beta-4) — the recovery peptide.

Read full guide · 9 min read →

Research

Studies & key findings

  • Promotes cardiac repair by activating integrin-linked kinase (ILK) in epicardial progenitor cells, mobilizing them to regenerate damaged myocardium after MI.
  • Phase 1 RCT in healthy volunteers (2010) confirmed IV thymosin β4 was safe and well-tolerated, clearing a key hurdle for clinical development.

10 peer-reviewed sources cited — clinical, preclinical, and regulatory.

Read full research →
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