Epithalon (Epitalon)Cellular PeptideSafety Rating 7/10

TypeSynthetic tetrapeptide
CAS307297-39-8
MW390.35 g/mol
AAs4 (tetrapeptide)
Primary research areaLongevity / telomere research

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose range5–10 mg/day (Khavinson protocols)source ↗
AdministrationSubcutaneous or intramuscular injection
Half-lifeNot well characterized (short)
Safety7/10 · Not FDA-approved
NCAA D1Not listed

Price Comparison

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Overview

About Epithalon

Mechanism of action

Stimulates telomerase activity, lengthening telomeres; regulates melatonin production via pineal gland; antioxidant; modulates neuroendocrine function; restores circadian rhythms.

Safety profile

Generally very well-tolerated. Minor injection site reactions. Long-term human safety data limited but decades of Russian research show safety. · Russian clinical studies in elderly patients showed safety; telomerase activation; theoretical cancer concern unproven

Storage

Stability & handling

❄️Lyophilized (powder)−20°Cup to 2 years
💉Reconstituted2–8°Cup to 30 days
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Safety & Interactions

Contraindications & Drug Interactions

Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.

! CautionCaution

Active malignancy — telomerase activation theoretically supports cancer cell immortalization; data is mostly preclinical. Avoid during active cancer treatment.

Related pages

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Research

Studies & key findings

  • Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin that induces telomerase activity and elongates telomeres in human somatic cells — a potential molecular mechanism of lifespan extension.
  • Extends mean and maximum lifespan in Drosophila and mice; regulates melatonin-to-cortisol ratio in aged primates, supporting its role in circadian and neuroendocrine aging.

12 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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