Antioxidant & Detoxification Peptide
Glutathione
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Research details
Glutathione — research data
Half-lifeIV: ~10 minutes (plasma); intracellular half-life longer. Frequent dosing needed for sustained levels.
Regulatory statusFDA-approved (oral/IV forms)
NCAA D1Permitted
Overview
About Glutathione
Mechanism of action
Master endogenous antioxidant; neutralizes reactive oxygen species (ROS); regenerates vitamins C and E; supports liver detoxification (Phase II); modulates immune response.
Safety profile
Generally very safe. IV: rare hypersensitivity. High-dose long-term: possible zinc depletion, theoretical melanin suppression. · Endogenous antioxidant; very safe; rare allergic reactions; widely used in IV wellness
Storage
Stability & handling
Lyophilized (powder)−20°Cprotected from light
Reconstituted2–8°Cuse promptly
Research products are not for human use. Looking for clinician-supervised care instead? Compare licensed US telehealth programs that may offer provider-guided peptide protocols when clinically appropriate.
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Research
Studies & key findings
- The landmark Sechi et al. (1996) open-label study in 9 early Parkinson's patients treated with IV glutathione 600 mg twice daily for 30 days reported a ~42% average decline in disability scores, with benefits persisting 2–4 months post-treatment — results that remain unreplicated in larger controlled trials.
- A subsequent randomized, double-blind, placebo-controlled pilot trial (Hauser et al., 2009; 21 patients) found no significant difference in UPDRS motor scores between IV glutathione 1,400 mg three-times-weekly and placebo, though a trend toward mild symptomatic benefit was noted.