Sermorelin (GRF 1-29 / GHRH 1-29) is a synthetic 29-amino-acid peptide identical to the biologically active N-terminal fragment of human growth hormone-releasing hormone (GHRH), used to stimulate the body's own GH production.
Sermorelin Prices
97 vendors · 47 with an issuer-verified COA · lowest 10mg from $27.00 · checked
Where to buy Sermorelin: 97 vendors compared
| Vendor | Price | Actions |
|---|---|---|
| 3-test panelVerified COAVanguard Laboratory · Tested Aug 20, 2026 | $27.00 | Buy Sermorelin from Studz Peptides |
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Tracked every day
Sermorelin listing prices, tracked daily
The five cheapest in-stock package prices for Sermorelin on each collected day, and the vendors that most often held those places.
Five cheapest in-stock package prices per day
Listed package price before coupons, any vial size. This is not the coupon-adjusted lowest 10mg price used to rank the comparison.
- Cheapest$28.80
- 2nd cheapest$30.00
- 3rd cheapest$33.00
- 4th cheapest$35.00
- 5th cheapest$35.00
Vendors most often in the cheapest five
- AmiNexa21 days$35.000.0%
- Pantheon Peptides16 days$28.800.0%
- Rocky Mountain Compounds16 days$37.50last seen Oct 6, 20260.0%
- VAYN12 days$30.00last seen Sep 30, 20260.0%
- Cielo Peptides10 days$36.00last seen Oct 7, 20260.0%
- Anglo Peptides7 days$38.15last seen Oct 7, 20260.0%
- Chameleon Peptides6 days$36.00last seen Sep 27, 20260.0%
- Studz Peptides5 days$30.000.0%
Top 8 of 13 vendors that reached the cheapest five
Current market data
Sermorelin Price Report
A current summary of public listings after the price comparison above. Shipping and tax are not included.
The lowest current 10mg cost for Sermorelin is $27.00 from Studz Peptides. The median across vendors is $67.50.
- Lowest 10mg cost
- $27.00Studz Peptides
- Median 10mg cost
- $67.50One normalized offer per vendor
- Lowest package total
- $21.92Precisely Peptides · package size may differ
- Public COA coverage
- 99%96 of 97 vendors
What the market shows
PeptidePrices found 117 in-stock listings from 97 vendors, checked through Oct 10, 2026. The lowest 10mg cost is 60% below the vendor median of $67.50; 48 vendors (49%) fall below that median. 96 of 97 vendors (99%) publish public COA evidence.
A public COA link shows that a vendor publishes testing data. It does not prove that every listed vial has a matching current report. Match the product, strength, batch, and lot before relying on a report.
How this report is calculated
The headline and median use each vendor's lowest whole-package checkout cost to obtain at least 10mg. Smaller packages are multiplied until the target is met, while larger packages retain their full checkout price. The lowest package total is shown only as secondary context because package sizes differ. Known public coupon discounts are applied. Shipping, tax, and unverified promotions are excluded.
Research context
What is Sermorelin? Research, safety, and status
Sermorelin is a synthetic peptide made of the first 29 amino acids of human GHRH, the shortest fully active fragment of the native hormone. Rather than supplying growth hormone directly, it prompts the pituitary to release the body's own GH, working through the same receptor and the same feedback controls as natural GHRH.
It is unusual among anti-aging peptides in having a real regulatory pedigree: it was FDA-approved as Geref for pediatric GH deficiency and as a diagnostic agent before being withdrawn in 2008 for purely commercial reasons. That history, plus a 2013 FDA confirmation that the withdrawal was not safety-related, is why licensed compounding pharmacies can legally prepare it by prescription today.
Key research takeaways
It works upstream of the pituitary, activating the same GHRHR that endogenous GHRH does, so GH release stays pulsatile and subject to somatostatin feedback, preserving the hypothalamic-pituitary axis rather than overriding it (the key contrast with exogenous GH).
It was genuinely FDA-approved (Geref) for pediatric GH deficiency and diagnostic use, then voluntarily withdrawn in 2008 for commercial reasons, the FDA confirmed in 2013 it was NOT withdrawn for safety/efficacy, which is what makes it legally compoundable today under Section 503A.
Adult anti-aging evidence is real but modest: small, short studies (often <20 participants, 4-6 months) on surrogate markers (IGF-1, body composition); the robust controlled data is in pediatric GH deficiency, a different clinical context.
It is explicitly PROHIBITED in sport, WADA S2.2 (peptide hormones / GH secretagogues), specifically S2.2.4 as a GHRH analog, banned at all times.
Sermorelin at a glance
PeptidePrices safety rating
8/10 · Previously FDA-approved
Mechanism
Synthetic analogue of first 29 amino acids of GHRH; binds pituitary GHRH receptors to stimulate natural pulsatile GH secretion. Preserves pituitary function unlike exogenous HGH.
Research areas
GH deficiency; anti-aging; body composition (lean mass, fat loss); sleep quality; bone density; children's growth disorders.
Regulatory / research status
FDA approved (for specific indications)
Half-life
~10-20 minutes. Bedtime single injection most effective.
Storage
Lyophilized vial: store at -20°C long-term or 2-8°C short-term, protected from light.
Reported side effects
Generally well-tolerated. May increase cortisol slightly.
Was FDA-approved (discontinued for commercial reasons, not safety); injection site reactions; well-tolerated Safety ratings summarize published clinical data, adverse-event reporting, and regulatory status. How PeptidePrices rates evidence. Research information only, not medical advice.
Study highlights
- Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous GHRH [GHRH(1-29)-NH2]; it stimulates endogenous pituitary GH secretion by binding pituitary GHRH receptors, unlike exogenous somatropin, it preserves the hypothalamic-pituitary feedback axis and physiological pulsatile GH secretion patterns.
- The Geref International Study Group multicenter trial (JCEM 1996, n=110 GHD children) demonstrated that once-daily subcutaneous sermorelin 30 µg/kg increased mean height velocity from 4.1 to 8.0 cm/year after 6 months; however, a direct comparison study (PMID 8329830) confirmed somatropin achieved faster growth (14.6 vs ~9 cm/year), establishing sermorelin as a less potent but mechanistically distinct alternative.
- Long-term administration of a GHRH(1-29) analogue in age-advanced men and women (Khorram et al., JCEM 1997) produced sustained increases in IGF-1, increased lean body mass (men), improved insulin sensitivity (men), increased skin thickness, and improved general well-being, supporting the rationale for sermorelin in adult GH insufficiency.
- Walker (Clin Interv Aging 2006) proposed sermorelin as a preferable approach to adult-onset GH insufficiency due to self-limiting action: because sermorelin stimulates GH only when hypothalamic regulatory signals permit, it carries lower risk of GH excess than direct somatropin injection, particularly relevant for safety-conscious adult use outside formal GHD.
Selected references
- Once Daily Subcutaneous GHRH Therapy Accelerates Growth in GH-Deficient Children During the First Year (Geref International Study Group) · Journal of Clinical Endocrinology & Metabolism, 1996
- Endocrine and Metabolic Effects of Long-Term Administration of GHRH(1-29)-NH2 in Age-Advanced Men and Women · Journal of Clinical Endocrinology & Metabolism, 1997
- A Comparative Study of Growth Hormone and GH-Releasing Hormone(1-29)-NH2 for Stimulation of Growth in Children with GH Deficiency · Acta Paediatrica Supplement, 1993
- Sermorelin: A Review of Its Use in the Diagnosis and Treatment of Children with Idiopathic Growth Hormone Deficiency · BioDrugs, 1999
- Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency? · Clinical Interventions in Aging, 2006
- Geref (Sermorelin Acetate) NDA 020443, Center for Drug Evaluation and Research · FDA, 1997
Research products are not for human use. Looking for clinician-supervised care instead? Compare licensed US telehealth programs that may offer provider-guided peptide protocols when clinically appropriate.
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