SermorelinSecretagogue PeptideSafety Rating 8/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Save ~94% vs Manufacturer direct
Research-grade Sermorelin is for laboratory and research use only, not approved for human consumption. Always consult a licensed physician before working with any compound. Geref discontinued 2008 by manufacturer. Sermorelin now available primarily through compounding pharmacies (~$200-400/mo) and research vendors. No direct-from-Pfizer pricing remains.
See all Sermorelin vendors →Price Comparison
Compare vendors · per 5mg
| Vendor | Price | $ / mg | Updated | |
|---|---|---|---|---|
| Ascension PeptidesBest $/mgCOA ✓ · 3P | $42.50 | $4.25 | Apr 16, 2026 | Buy → |
| Petratide ScienceCOA ✓ · 3P | $54.95 | $5.50 | May 14, 2026 | Buy → |
| Evolve PeptidesCOA ✓ · 3P | $63.75 | $6.38 | Apr 22, 2026 | Buy → |
| PeptiraCOA ✓ · 3P | $69.00 | $6.90 | May 14, 2026 | Buy → |
| Chameleon PeptidesCOA ✓ · 3P | $72.00 | $7.20 | Apr 17, 2026 | Buy → |
Overview
About Sermorelin
Mechanism of action
Synthetic analogue of first 29 amino acids of GHRH; binds pituitary GHRH receptors to stimulate natural pulsatile GH secretion. Preserves pituitary function unlike exogenous HGH.
Safety profile
Injection site reactions, flushing, headache, dizziness, water retention. Generally well-tolerated. May increase cortisol slightly. · Was FDA-approved (discontinued for commercial reasons, not safety); injection site reactions; well-tolerated
Storage
Stability & handling
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Safety & Interactions
Contraindications & Drug Interactions
Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.
Active malignancy.
Intracranial lesions — tumors may affect GH response unpredictably.
Insulin resistance and Type 2 diabetes — monitor glucose.
Related pages
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Research
Studies & key findings
- Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous GHRH [GHRH(1-29)-NH2]; it stimulates endogenous pituitary GH secretion by binding pituitary GHRH receptors — unlike exogenous somatropin, it preserves the hypothalamic-pituitary feedback axis and physiological pulsatile GH secretion patterns.
- The Geref International Study Group multicenter trial (JCEM 1996, n=110 GHD children) demonstrated that once-daily subcutaneous sermorelin 30 µg/kg increased mean height velocity from 4.1 to 8.0 cm/year after 6 months; however, a direct comparison study (PMID 8329830) confirmed somatropin achieved faster growth (14.6 vs ~9 cm/year), establishing sermorelin as a less potent but mechanistically distinct alternative.