CJC-1295 (No DAC)Secretagogue PeptideBlendSafety Rating 7/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
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| Vendor | Price | $ / mg | Updated | |
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| Puratek PeptidesBest $/mgCOA ✓ · 3P | $40.46 | $4.05 | May 19, 2026 | Buy → |
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Overview
About CJC-1295
Mechanism of action
GHRH analogue; binds GHRH receptors on pituitary somatotrophs to stimulate pulsatile GH secretion. No DAC version has shorter action for more physiological GH pulses.
Safety profile
Water retention, numbness/tingling, insulin resistance (at high doses), fatigue, potential cortisol/prolactin increase. · Studied in human PK trials; well-tolerated; water retention, tingling reported; short-acting
Storage
Stability & handling
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Safety & Interactions
Contraindications & Drug Interactions
Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.
Active malignancy — sustained GH/IGF-1 elevation is a theoretical tumor growth risk.
Type 2 diabetes or pre-diabetes — reduced insulin sensitivity reported with chronic GH agonism.
Ipamorelin / GHRP-2 / GHRP-6 — standard synergistic combo, amplifies GH pulses.
Blend
Component Compounds
CJC-1295 (No DAC)
GHRH receptor agonist · half-life 30 min–2 hrs
Ipamorelin
Aib-His-D-2-Nal-D-Phe-Lys-NH₂Ghrelin receptor (GHSR-1a) agonist · no cortisol/prolactin elevation
Related pages
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CJC-1295 Guide
CJC-1295 with DAC vs without DAC — the complete breakdown.
Read full guide · 9 min read →Research
Studies & key findings
- A GHRH analogue that extends the half-life of growth hormone-releasing hormone pulses, enabling once-daily or twice-weekly dosing versus native GHRH's minutes-long activity.
- Paired with ipamorelin, CJC-1295 produces a robust, physiological GH pulse without blunting the normal GH feedback cycle.