PeptidePrices safety rating
6/10 · Not FDA-approved
PE-22-28 Prices
14 vendors · 7 with an issuer-verified COA · lowest 10mg from $25.00 · checked
Where to buy PE-22-28: 14 vendors compared
| Vendor | Price | Actions |
|---|---|---|
| 3-test panelVerified COAFreedom Diagnostics · Tested Aug 8, 2026 | $25.00 | Buy PE-22-28 from Rocky Mountain Compounds |
| $27.00 | Buy PE-22-28 from Ararat Peptides | |
| 5-test panelVerified COAFreedom Diagnostics · Tested Jul 6, 2026 | $33.74 | Buy PE-22-28 from Modern Research Peptides |
| $44.99 | Buy PE-22-28 from MS Peptides | |
| $52.20 | Buy PE-22-28 from Nationwide Peptides | |
| 2-test panelVerified COAJanoshik · Tested Apr 17, 2026 | $52.49 | Buy PE-22-28 from Paramount Peptides |
| 4-test panelVerified COAKovera Labs · Tested Sep 18, 2026 | $52.802 × 8mg packages · 10mg totalChecked Oct 5 | Buy PE-22-28 from Real Peptides |
| $60.002 × 5mg packages · 10mg totalChecked today | Buy PE-22-28 from Pure Peptides | |
| $61.59 | Buy PE-22-28 from Cenexa Labs | |
| 6-test panelVerified COABioViridian | $63.00 | Buy PE-22-28 from American Peptides |
| 4-test panelVerified COAFreedom Diagnostics · Tested Feb 16, 2026 | $63.74 | Buy PE-22-28 from SomaChems |
| $90.00 | Buy PE-22-28 from Atomik Labz | |
| 2-test panelVerified COAOptima Labs | $92.2710mg packageChecked Sep 20 | Buy PE-22-28 from Peptides Lab UK |
| $100.44 | Buy PE-22-28 from Atlas Longevity |
Tracked every day
PE-22-28 listing prices, tracked daily
The five cheapest in-stock package prices for PE-22-28 on each collected day, and the vendors that most often held those places.
Five cheapest in-stock package prices per day
Listed package price before coupons, any vial size. This is not the coupon-adjusted lowest 10mg price used to rank the comparison.
- Cheapest$29.00
- 2nd cheapest$30.00
- 3rd cheapest$30.00
- 4th cheapest$44.99
- 5th cheapest$49.99
Vendors most often in the cheapest five
- Nationwide Peptides26 days$29.000.0%
- MS Peptides19 days$49.990.0%
- Rocky Mountain Compounds18 days$30.00last seen Oct 6, 20260.0%
- Modern Research Peptides15 days$44.990.0%
- Real Peptides11 days$26.40last seen Oct 5, 20260.0%
- American Peptides4 days$70.00last seen Sep 24, 20260.0%
- Ararat Peptides2 days$30.000.0%
- Pure Peptides2 days$30.000.0%
Top 8 of 9 vendors that reached the cheapest five
Current market data
PE-22-28 Price Report
A current summary of public listings after the price comparison above. Shipping and tax are not included.
The lowest current 10mg cost for PE-22-28 is $25.00 from Rocky Mountain Compounds. The median across vendors is $56.40.
- Lowest 10mg cost
- $25.00Rocky Mountain Compounds
- Median 10mg cost
- $56.40One normalized offer per vendor
- Lowest package total
- $25.00Rocky Mountain Compounds · package size may differ
- Public COA coverage
- 93%13 of 14 vendors
What the market shows
PeptidePrices found 16 in-stock listings from 14 vendors, checked through Oct 9, 2026. The lowest 10mg cost is 56% below the vendor median of $56.40; 7 vendors (50%) fall below that median. 13 of 14 vendors (93%) publish public COA evidence.
A public COA link shows that a vendor publishes testing data. It does not prove that every listed vial has a matching current report. Match the product, strength, batch, and lot before relying on a report.
How this report is calculated
The headline and median use each vendor's lowest whole-package checkout cost to obtain at least 10mg. Smaller packages are multiplied until the target is met, while larger packages retain their full checkout price. The lowest package total is shown only as secondary context because package sizes differ. Known public coupon discounts are applied. Shipping, tax, and unverified promotions are excluded.
Research context
What is PE-22-28? Research, safety, and status
PE-22-28 at a glance
Mechanism
Optimized analogue of spadin; selective TREK-1 (K2P potassium channel) blocker; activates serotonergic neurotransmission; antidepressant effects via BDNF upregulation; fast-acting.
Research areas
Depression; treatment-resistant depression; fast-acting antidepressant; anxiety; BDNF upregulation; cognitive enhancement.
Regulatory / research status
Research / preclinical only
Half-life
Not well-established.
Storage
Lyophilized vial: store at -20°C long-term or 2-8°C short-term, protected from light.
Reported side effects
Very limited human data. Well-tolerated in animal studies. Theoretical serotonergic side effects.
Spadin analog; TREK-1 inhibitor; animal data favorable; no proven harms; early stage Safety ratings summarize published clinical data, adverse-event reporting, and regulatory status. How PeptidePrices rates evidence. Research information only, not medical advice.
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