Price Comparison
P21 Peptide
Neurotrophic Peptide
2 of 2 vendors
| Vendor | Price | 10mg cost | Updated | Actions |
|---|---|---|---|---|
| SomaChems 8.5/10 COA ✓Ships: USCredit card · eCheck Verification & shipping8.5/10 COA ✓Ships: USCredit card · eCheck | $72.24 | $72.24Checked may 14, 2026 | May 14, 2026 | Buy P21 Peptide from SomaChems |
| Nationwide Peptides 6/10 COA ✓Ships: USCredit/debit card Verification & shipping6/10 COA ✓Ships: USCredit/debit card | $87.30 | $174.60Checked aug 5, 2026 | Aug 5, 2026 | Buy P21 Peptide from Nationwide Peptides |
Research details
P21 Peptide — research data
Half-lifeNot established in humans. Daily dosing in research protocols.
Regulatory statusNot FDA-approved
NCAA D1Not listed
Overview
About P21 Peptide
Mechanism of action
Tetrapeptide derived from ciliary neurotrophic factor (CNTF); activates gp130 signaling; promotes BDNF expression and neurogenesis; enhances synaptic plasticity; reduces Alzheimer's tau pathology.
Safety profile
Very limited human data. Generally well-tolerated in animal studies. · BDNF mimetic; limited data but no proven harms; theoretical mechanism favorable
Storage
Stability & handling
Lyophilized (powder)−20°Clong-term stable
Reconstituted2–8°Cwithin 30 days
Related pages
More on P21 Peptide
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Frequently Researched Together
Research
Studies & key findings
- p21/CDKN1A is the primary effector of p53-driven cell cycle arrest and a central mediator of cellular senescence; it can function as both a classical tumor suppressor (arresting damaged cells) and, paradoxically, as a proto-oncogenic survival factor in established tumors, with its role determined by cellular context, subcellular localization, and interaction partners.
- A 2021 Science study found that p21-activated cells produce a bioactive secretome (PASP, including CXCL14) that recruits macrophages for immunosurveillance of stressed and precancerous cells — a tumor-suppressive mechanism; persistent p21 expression triggers M1 macrophage polarization and cytotoxic T-cell recruitment, placing stressed cells under immune clearance.