P21 Peptide Price Comparison — Compare 3 Vendors
Price Comparison
Compare vendors · per 10mg
| Vendor | Price | $ / mg | Updated | |
|---|---|---|---|---|
| SomaChems7/10 | $67.99 | $6.80 | May 14, 2026 | Buy → |
| Modern Aminos9/10 | $98.00 | $9.80 | May 14, 2026 | Buy → |
| Core Peptides5.5/10 | $116.00 | $23.20 | Apr 16, 2026 | Buy → |
Research details
P21 Peptide — research data
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Overview
About P21 Peptide
Mechanism of action
Tetrapeptide derived from ciliary neurotrophic factor (CNTF); activates gp130 signaling; promotes BDNF expression and neurogenesis; enhances synaptic plasticity; reduces Alzheimer's tau pathology.
Safety profile
Very limited human data. Generally well-tolerated in animal studies. · BDNF mimetic; limited data but no proven harms; theoretical mechanism favorable
Storage
Stability & handling
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Frequently Researched Together
Research
Studies & key findings
- p21/CDKN1A is the primary effector of p53-driven cell cycle arrest and a central mediator of cellular senescence; it can function as both a classical tumor suppressor (arresting damaged cells) and, paradoxically, as a proto-oncogenic survival factor in established tumors, with its role determined by cellular context, subcellular localization, and interaction partners.
- A 2021 Science study found that p21-activated cells produce a bioactive secretome (PASP, including CXCL14) that recruits macrophages for immunosurveillance of stressed and precancerous cells — a tumor-suppressive mechanism; persistent p21 expression triggers M1 macrophage polarization and cytotoxic T-cell recruitment, placing stressed cells under immune clearance.