P21 PeptideNeurotrophic PeptideSafety Rating 6/10
TypeCNTF-derived neurotrophic peptide
CASNot standardized
MWNot well characterized publicly
AAsNot well characterized publicly
Primary research areaNeurotrophic research
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
AdministrationSubcutaneous (research) or intraperitoneal (mice)
Half-lifeNot well characterized in humans
Safety6/10 · Not FDA-approved
NCAA D1Not listed
Price Comparison
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Overview
About P21 Peptide
Mechanism of action
Tetrapeptide derived from ciliary neurotrophic factor (CNTF); activates gp130 signaling; promotes BDNF expression and neurogenesis; enhances synaptic plasticity; reduces Alzheimer's tau pathology.
Safety profile
Very limited human data. Generally well-tolerated in animal studies. · BDNF mimetic; limited data but no proven harms; theoretical mechanism favorable
Storage
Stability & handling
Lyophilized (powder)−20°Clong-term stable
Reconstituted2–8°Cwithin 30 days
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Research
Studies & key findings
- p21/CDKN1A is the primary effector of p53-driven cell cycle arrest and a central mediator of cellular senescence; it can function as both a classical tumor suppressor (arresting damaged cells) and, paradoxically, as a proto-oncogenic survival factor in established tumors, with its role determined by cellular context, subcellular localization, and interaction partners.
- A 2021 Science study found that p21-activated cells produce a bioactive secretome (PASP, including CXCL14) that recruits macrophages for immunosurveillance of stressed and precancerous cells — a tumor-suppressive mechanism; persistent p21 expression triggers M1 macrophage polarization and cytotoxic T-cell recruitment, placing stressed cells under immune clearance.