HGH 191AA (Somatropin)Growth HormoneSafety Rating 8/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
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| Vendor | Price | $ / IU | Updated | |
|---|---|---|---|---|
| LeoLab RxBest $/IUCOA ✓ · 3P | $30.00 | $3.00 | May 14, 2026 | Buy → |
Overview
About HGH 191AA
Mechanism of action
Recombinant human growth hormone; binds GHR; activates JAK2/STAT5 pathway; stimulates IGF-1 production; promotes protein synthesis, lipolysis, gluconeogenesis, and bone growth.
Safety profile
Water retention, carpal tunnel, joint pain, insulin resistance, acromegaly (high dose), potential cancer promotion, glucose elevation. · FDA-approved for deficiency; joint pain, edema, insulin resistance at higher doses; cancer surveillance
Storage
Stability & handling
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Safety & Interactions
Contraindications & Drug Interactions
Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.
Active malignancy — GH is contraindicated in active neoplasia.
Acute critical illness — increased mortality in ICU patients per FDA warning.
Prader-Willi patients with severe obesity or sleep apnea — sudden death reports.
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Research
Studies & key findings
- Recombinant human GH (somatropin, 191 amino acids identical to pituitary GH) is approved for adult GHD treatment; a 2022 KIMS registry analysis of 15,809 GH-treated patients over a mean 5.3 years confirmed that overall cancer incidence was comparable to the general population, substantially supporting long-term safety for adult replacement therapy.
- In adults with GHD, somatropin restores normal body composition by reducing fat mass (predominantly visceral) and increasing lean body mass, improves cardiac function, normalizes atherogenic lipid profiles (decreased LDL, increased HDL), and improves quality of life scores — effects confirmed in multiple placebo-controlled trials and systematic review.