We found no peer-reviewed study of N-Acetyl Semax Amidate itself. Not in animals, not in humans. Every effect claimed for it is borrowed from parent Semax.
N-Acetyl Semax Amidate Prices
13 vendors · 1 with an issuer-verified COA · lowest 10mg from $28.06 · checked
Where to buy N-Acetyl Semax Amidate: 13 vendors compared
Tracked every day
N-Acetyl Semax Amidate listing prices, tracked daily
The five cheapest in-stock package prices for N-Acetyl Semax Amidate on each collected day, and the vendors that most often held those places.
No collected listings for this compound yet.
Current market data
N-Acetyl Semax Amidate Price Report
A current summary of public listings after the price comparison above. Shipping and tax are not included.
The lowest current 10mg cost for N-Acetyl Semax Amidate is $28.06 from Pure Peptides UK. The median across vendors is $46.74.
- Lowest 10mg cost
- $28.06Pure Peptides UK
- Median 10mg cost
- $46.74One normalized offer per vendor
- Lowest package total
- $28.06Pure Peptides UK · package size may differ
- Public COA coverage
- 92%12 of 13 vendors
What the market shows
PeptidePrices found 13 in-stock listings from 13 vendors, checked through Oct 8, 2026. The lowest 10mg cost is 40% below the vendor median of $46.74; 6 vendors (46%) fall below that median. 12 of 13 vendors (92%) publish public COA evidence.
A public COA link shows that a vendor publishes testing data. It does not prove that every listed vial has a matching current report. Match the product, strength, batch, and lot before relying on a report.
How this report is calculated
The headline and median use each vendor's lowest whole-package checkout cost to obtain at least 10mg. Smaller packages are multiplied until the target is met, while larger packages retain their full checkout price. The lowest package total is shown only as secondary context because package sizes differ. Known public coupon discounts are applied. Shipping, tax, and unverified promotions are excluded.
Research context
What is N-Acetyl Semax Amidate? Research, safety, and status
Semax is a seven-residue peptide built in the Soviet era from the 4-7 stretch of ACTH (Met-Glu-His-Phe), with Pro-Gly-Pro added at the end. FDA's 2026 review describes it as keeping the neurobehavioral activity of ACTH(4-10) without the hormonal effects, and notes the Pro-Gly-Pro tail is thought to slow breakdown by peptidases.
N-Acetyl Semax Amidate takes that same seven-residue chain and changes both ends. The N-terminus gets an acetyl group, so the methionine no longer has a free amine. The C-terminus becomes an amide, so the final proline no longer carries a free carboxylic acid. No residues are added or swapped.
Key research takeaways
The reason to cap the N-terminus is real. Rat studies show Semax is broken down mainly from the N-terminal end, by aminopeptidases. A 2019 review by the Semax developers says N-acetyl Semax was the most promising of the stabilized versions they tried.
The C-terminal amide has no published Semax data behind it that we could find. Semax already ends in Pro-Gly-Pro, which its developers added for stability.
Acetylation changes more than shelf life. In one cell study, N-acetyl Semax lost the parent peptide's protection against copper toxicity, and the authors tied that to the free N-terminus.
N-Acetyl Semax Amidate at a glance
PeptidePrices safety rating
5/10 · Not FDA-approved
Mechanism
Modified form of Semax (an ACTH(4-10) analog) with an acetylated N-terminus and amidated C-terminus, presumed to resist enzymatic breakdown. Its pharmacology has not been characterised separately from Semax; one cell study found acetylation changed Semax's metal-binding behaviour.
Research areas
Nootropic and neuropeptide-analog research. Human clinical benefit of this modified form is not established, and Semax's Russian registration does not apply to it.
Regulatory / research status
Research / preclinical only
Half-life
Not established in direct human pharmacokinetic studies.
Storage
Lyophilized vial: store at -20°C long-term or 2-8°C short-term, protected from light.
Reported side effects
No published human safety data exist for the N-acetyl amidate form. Effects of the parent peptide Semax cannot be assumed to carry over, and research-market purity and identity vary.
Modified Semax analog with essentially no human data; Semax's Russian approval does not transfer. Safety ratings summarize published clinical data, adverse-event reporting, and regulatory status. How PeptidePrices rates evidence. Research information only, not medical advice.
Study highlights
- We found no peer-reviewed study of N-Acetyl Semax Amidate itself. Not in animals, not in humans. Every effect claimed for it is borrowed from parent Semax.
- The reason to cap the N-terminus is real. Rat studies show Semax is broken down mainly from the N-terminal end, by aminopeptidases. A 2019 review by the Semax developers says N-acetyl Semax was the most promising of the stabilized versions they tried.
- The C-terminal amide has no published Semax data behind it that we could find. Semax already ends in Pro-Gly-Pro, which its developers added for stability.
- Acetylation changes more than shelf life. In one cell study, N-acetyl Semax lost the parent peptide's protection against copper toxicity, and the authors tied that to the free N-terminus.
Selected references
- N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes · PubMed, 1991
- Degradation of ACTH/MSH(4-10) and its synthetic analog semax by rat serum enzymes: an inhibitor study · PubMed, 1993
- [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration] · PubMed, 2006
- [Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation] · PubMed, 2006
- Stability of Semax acetyl to proteolysis in various biological media · PubMed, 2013
- Study of proteolysis of Semax analogues with different N-terminal amino acids by carboxypeptidases · PubMed, 2013
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