GHK-Cu (Copper Peptide)Dermal CompoundSafety Rating 8/10

TypeCopper-peptide complex
CAS89030-95-5
MW340.38 g/mol (free) / 401.91 g/mol (with Cu)
AAs3 (tripeptide)
Primary research areaSkin / wound healing research

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose rangeTopical 0.05%–2% (cosmetic formulations); research on fibroblasts at 0.01–100 nMsource ↗
AdministrationTopical (cream/serum); sometimes SC injection for research
Half-lifeNot applicable (topical)
Safety8/10 · Not FDA-approved (cosmetic)
NCAA D1Not listed

Price Comparison

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25 vendors competing

VendorPrice$ / mgUpdated
Amino ClubBest $/mgCOA ✓ · 3P$23.99$29.99−20% · code PEPTIDEPRICES$0.24May 14, 2026Buy →
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Red River PeptidesCOA ✓ · 3PAvailable on backorder$34.00$40.00−15% · code PEPTIDEPRICES$0.34May 19, 2026Buy →
Petratide ScienceCOA ✓ · 3P$39.95$0.40May 14, 2026Buy →
LA PeptidesCOA on request$39.99$0.40May 14, 2026Buy →

Overview

About GHK-Cu

Mechanism of action

Binds copper ions, stimulates collagen and glycosaminoglycan synthesis, activates TGF-beta, promotes wound healing, antioxidant, anti-inflammatory, modulates ~4,000 genes.

Safety profile

Topical: generally very safe. Injectable: injection site reactions; copper toxicity risk at very high doses (rare at standard doses). · Extensive topical safety; naturally occurring peptide; well-tolerated across all routes studied

Storage

Stability & handling

❄️Lyophilized (powder)−20°Cup to 2 years
💉Reconstituted2–8°Cup to 30 days
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Safety & Interactions

Contraindications & Drug Interactions

Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.

! CautionCaution

Wilson's disease — copper overload risk from long-term high-dose systemic GHK-Cu.

ℹ NoteCaution

Active melanoma — GHK-Cu effects on tumor biology are complex; avoid systemic use during treatment.

Related pages

More on GHK-Cu

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Research

Studies & key findings

  • A naturally occurring tripeptide that modulates over 4,000 human genes, including upregulation of collagen, elastin, and anti-inflammatory pathways.
  • Promotes wound healing, nerve regeneration, anti-inflammatory signaling, and antioxidant activity — making it one of the most studied cosmetic/regenerative peptides.

3 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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