Safety Profile

HGH 191AA

Updated today

Growth Hormone
7/10Good
Primary use: Growth hormone research

Regulatory Status

FDA-approved (various)

Safety Summary

  • FDA-approved for deficiency, but off-label/high-dose use carries real risk: insulin resistance/diabetes, carpal tunnel, and acromegaly-like changes with chronic use. Contraindicated in active cancer and acute critical illness (increased ICU mortality).

HGH 191AA's 7/10 rating reflects mixed evidence — some clinical data and a meaningful research base, but enough open questions that researchers should weight personal risk tolerance heavily. Long-term safety in the population segment most likely to use this compound (off-label) is the area with the thinnest published evidence. Researchers often consider Sermorelin and CJC-1295 (With DAC) as alternatives in the same category — see the related-compounds section below for safety comparisons.

Molecular Profile

TypeRecombinant 191-aa growth hormone
Molecular Weight22,124 Da
Amino Acids191
CAS Number12629-01-5

Storage

Lyophilized2–8°C, per labeling (often refrigerated)
Reconstituted2–8°C, within 14 days
  • Biologic — do NOT freeze reconstituted
  • Protect from light
  • Do not shake

Methodology

How we rate peptide safety

Every compound in our index gets a 1–10 safety score based on four weighted factors. The score reflects known research-use risk — not medical advice.

  • 40% — Clinical evidence. Volume of peer-reviewed trials, sample sizes, duration, and consistency of outcomes. FDA-approved compounds anchor the top end (8–10); preclinical-only compounds cap at 6.
  • 30% — Adverse-event profile. Severity and frequency of reported side effects, including GI events, cardiovascular signals, hypoglycemia, and long-term organ effects.
  • 20% — Regulatory status. FDA approval, EMA approval, or status in active clinical trials. Compounds under safety warnings are penalized.
  • 10% — Community-reported outcomes. Reddit, forum, and published case-report signal beyond formal trials. Used as a late-stage tiebreaker, not a leading factor.
9–10Well-studied, FDA-approvedLarge-trial evidence, established long-term safety. Examples: semaglutide, tesamorelin at approved doses.
7–8Mostly safe, some caveatsPhase 2/3 evidence or long community track record with known manageable side effects. Routine monitoring recommended.
5–6Mixed dataLimited clinical trials, mostly community/preclinical data. Real but uncertain risk profile.
3–4Caution advisedKnown side-effect patterns, thin safety data, or compounds under active regulatory scrutiny.
1–2Significant risk signalsDocumented serious adverse events (cardiovascular, hepatotoxicity, contamination) or withdrawn regulatory status.

Safety ratings are derived from published clinical data, FDA approval status, and community-reported outcomes. They are not medical advice. Always consult a healthcare professional before using any research compound.

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