Snap-8Dermal PeptideSafety Rating 8/10

TypeSynthetic neuropeptide (SNAP-25 mimetic)
CAS868844-74-0
MW1,073.2 g/mol
AAs8
Primary research areaTopical / dermatology research

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose rangeTopical: 4–10% concentration in serums/creams. No injection protocol; cosmetic-only peptide.
AdministrationInjection / Topical
Safety8/10 · Cosmetic use (topical)
NCAA D1Not listed

Price Comparison

Compare vendors · per 5mg

8 vendors competing

VendorPrice$ / mgUpdated
Guru PeptidesBest $/mgCOA unknown$24.99$2.50May 16, 2026Buy →
Evolve PeptidesCOA ✓ · 3P$29.75$35.00−15% · code PEPTIDEPRICES$2.98Apr 22, 2026Buy →
TRS ResearchCOA unknown$30.00$3.00May 14, 2026Buy →
Apex Peptide SupplyCOA ✓ · 3P$34.99$3.50May 14, 2026Buy →
Apollo Peptide SciencesCOA ✓ · 3P$45.00$4.50Apr 20, 2026Buy →

Overview

About Snap-8

Mechanism of action

Octapeptide analogue of SNAP-25 (synaptosomal protein); competes with SNAP-25 for SNARE complex formation; reduces acetylcholine-driven muscle contraction at neuromuscular junction; Botox-like effect topically.

Safety profile

Very well-tolerated topically. Rare: mild skin irritation. Essentially no systemic effects. · Topical cosmetic peptide; excellent safety profile; well-tolerated; widely used

Storage

Stability & handling

❄️Lyophilized (powder)2–8°Cstable long-term
💉Reconstitutedroom temperaturestable in formulation
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Related pages

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Research

Studies & key findings

  • Octapeptide (Acetyl Octapeptide-3 / SNAP-8) that competitively inhibits the SNARE complex formation, reducing neurotransmitter release at the neuromuscular junction — a topical botulinum toxin-alternative mechanism.
  • Clinical data from Lipotec reported a ~63% reduction in wrinkle depth on the forehead after 28 days in a double-blind vehicle-controlled study.

4 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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