5-Amino-1MQ research

The 5-Amino-1MQ evidence base cited here is 8 sources — 8 preclinical. Critically, that evidence is almost entirely preclinical (animal and in-vitro) — no human clinical trials are cited, so efficacy and safety in people remain unproven. Regulatory status: Not FDA-approved.

• 5-Amino-1MQ is a small molecule (not a peptide) that inhibits the enzyme NNMT (nicotinamide N-methyltransferase), which in turn helps preserve cellular NAD+ and supports mitochondrial and metabolic function.
• It is taken orally; reported animal data put oral bioavailability around 38% with an oral half-life near 7 hours.
• The most-cited findings are improved muscle function and grip strength in aged mice and modest fat loss in obese-mouse models — promising, but a long way from established human benefit.

5-Amino-1MQ (5-amino-1-methylquinolinium) is a research compound studied for metabolism and longevity. Mechanistically it is an inhibitor of NNMT, an enzyme that consumes the NAD+ precursor pathway; by blunting NNMT it is proposed to raise or preserve cellular NAD+ and, through that, support mitochondrial function, energy metabolism, and possibly fat metabolism.

It is a small-molecule, orally available inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT methylates nicotinamide (a precursor in the NAD+ salvage pathway); over-activity of NNMT is associated with depleted NAD+ and metabolic dysfunction in fat and muscle tissue. Inhibiting the enzyme is the lever 5-Amino-1MQ is designed to pull.

• Oral bioavailability ~38% (rat data)
• Time to peak: roughly 48 minutes
• Half-life: ~7 hours oral (≈3.8 hours IV in rats); largely cleared within ~1.7 days

All pharmacokinetic figures are from animal studies. Human PK has not been characterized.

• Rat pharmacokinetic study (2021): established the ~38% oral bioavailability and oral/IV half-lives.

These are animal results. They motivate human research but do not establish that 5-Amino-1MQ works — or is safe — in people.

• Store cool and dry, away from light and moisture.
• Quality indicators: uniform white-to-off-white capsules/powder, sealed packaging, and a third-party COA showing >98% purity with heavy-metals testing.
• Warning signs: moisture damage, clumping or stickiness, discoloration, or a strong chemical odor (possible contamination or degradation).

5-Amino-1MQ is not approved by the FDA or any regulatory agency for any indication. It is sold as a research chemical for laboratory use only and is not intended for human consumption.

All citations link to the original source (PubMed, journal site, or regulatory filing). Independent research database — no vendor influence on what's cited.