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Research details
Ziconotide — research data
Regulatory statusFDA-approved (Prialt)
NCAA D1Not listed
Overview
About Ziconotide
Mechanism of action
N-type voltage-gated calcium channel blocker from cone snail venom omega-conotoxin MVIIA
Safety profile
Dizziness, nausea, confusion, severe neuropsychiatric effects · Carries an FDA black-box warning for severe psychiatric symptoms and cognitive impairment. Very narrow therapeutic window; intrathecal administration only. Approved for severe chronic pain but high-risk.
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