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Research details

Triptorelin — research data

Half-life~7.6 hours. Depot formulations last 1–3 months.
Regulatory statusFDA-approved (Trelstar)
NCAA D1Banned

Overview

About Triptorelin

Mechanism of action

Potent GnRH agonist; initial stimulation then desensitization/downregulation of pituitary GnRH receptors; with pulsatile use causes LH/FSH/testosterone surge; continuous use causes chemical castration.

Safety profile

PCT use: temporary testosterone spike, possible E2 surge, then reset. Continuous: hot flashes, testosterone suppression, bone loss. Depot: castration-level testosterone. · Approved for prostate cancer; standard GnRH agonist profile; well-established

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