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Research details

Orexin A — research data

Half-life~30 minutes. Limited bioavailability via non-intranasal routes.
Regulatory statusNot FDA-approved
NCAA D1Not listed

Overview

About Orexin A

Mechanism of action

Endogenous neuropeptide produced in hypothalamus; binds OX1R and OX2R; promotes wakefulness and arousal; regulates energy homeostasis, appetite, and reward pathways.

Safety profile

Limited human data. Potential: anxiety, appetite changes, cardiovascular effects. Intranasal generally well-tolerated in studies. · Endogenous neuropeptide; limited human data; cardiovascular effects in animals; no proven major harms

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