MGF (Mechano Growth Factor)Growth Factor Analog PeptideSafety Rating 6/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
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Overview
About MGF
Mechanism of action
Alternatively spliced isoform of IGF-1 (Ec peptide); released in response to mechanical load/muscle damage; activates and proliferates satellite (muscle stem) cells; distinct from systemic IGF-1 — acts locally at damage site; does not bind IGFBPs.
Safety profile
Hypoglycemia risk, water retention, injection site reactions. Rapid degradation limits systemic effects vs. PEG-MGF. · IGF-1 splice variant; limited data; localized action; no proven major harms in available studies
Storage
Stability & handling
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Research
Studies & key findings
- MGF is generated by alternative splicing of the IGF-1 gene in mechanically stressed skeletal muscle; the splice variant produces an E-domain peptide that acts transiently and locally to activate muscle satellite cells, initiating a proliferative burst before longer-lived IGF-1Ea drives terminal differentiation.
- Exercise-induced muscle damage in humans produces a rapid, transient upregulation of MGF mRNA within hours of eccentric contraction, with the synthetic MGF E peptide activating signaling pathways independent of the classic IGF-1 receptor, suggesting a distinct paracrine mechanism.