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Research details
Melatonin — research data
Half-life~45 minutes to 1 hour. Nightly dosing for sleep; cycle use for anti-aging protocols.
Regulatory statusNot FDA-approved (oral OTC)
NCAA D1Permitted
Overview
About Melatonin
Mechanism of action
Endogenous pineal hormone; binds MT1 and MT2 receptors; regulates circadian rhythm; potent antioxidant; immunomodulatory; anti-inflammatory; anti-cancer properties via free radical scavenging; mitochondrial protective.
Safety profile
Daytime drowsiness, headache, dizziness, potential suppression of natural melatonin production with long-term high-dose use. Generally very safe. · Oral melatonin extremely safe; injectable less studied but same molecule; no major signals
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