LiraglutideGLP-1 PeptideSafety Rating 8/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
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Overview
About Liraglutide
Mechanism of action
GLP-1 receptor agonist (97% homology to human GLP-1); stimulates insulin secretion, inhibits glucagon, slows gastric emptying, reduces appetite. Daily injection (vs. weekly for semaglutide).
Safety profile
Nausea, vomiting, diarrhea, constipation; pancreatitis risk; thyroid C-cell tumor risk (rodents); gallbladder disease; injection site reactions. · Extensive data; GI side effects; thyroid warning (animal); cardiovascular benefit demonstrated
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Stability & handling
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Research
Studies & key findings
- The SCALE Obesity trial (NEJM 2015, n=3,731) demonstrated that liraglutide 3.0 mg as Saxenda produced a mean 8.4% body weight reduction vs 2.8% with placebo over 56 weeks — with 63.2% of participants achieving ≥5% weight loss, leading to FDA approval for chronic weight management.
- The LEADER cardiovascular outcomes trial (NEJM 2016, n=9,340) showed liraglutide 1.8 mg significantly reduced the MACE composite endpoint by 13% (HR 0.87, p=0.01) in T2D patients at high cardiovascular risk over a median 3.8 years — establishing the first cardiovascular mortality benefit for a GLP-1 agonist.