LinaclotideFDA ApprovedSafety Rating 8/10
Primary research areaIBS-C
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Research dose range72-290 mcg once daily
AdministrationOral capsule
Safety8/10 · FDA-approved (Linzess)
NCAA D1Not listed
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Overview
About Linaclotide
Mechanism of action
Guanylate cyclase-C agonist guanylin peptide analog; accelerates GI transit and fluid secretion
Safety profile
Diarrhea, abdominal pain; pediatric boxed warning · Approved for IBS-C/CIC; diarrhea most common; well-characterized safety
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