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Research details

Hyaluronic Acid — research data

Half-life~1–3 days (free HA); cross-linked filler formulations last 6–18 months.
Regulatory statusFDA-approved (various)
NCAA D1Permitted

Overview

About Hyaluronic Acid

Mechanism of action

Naturally occurring glycosaminoglycan; binds water molecules (holds 1000x its weight in water); lubricates joints via synovial fluid enhancement; stimulates collagen synthesis; anti-inflammatory via CD44 receptor.

Safety profile

Injection site swelling, bruising, pain. Rare: granuloma, vascular occlusion (filler use), hypersensitivity. Generally very safe. · Widely used; very rare vascular occlusion; generally extremely safe; biocompatible

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