HexarelinGH Secretagogue PeptideSafety Rating 6/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
Compare vendors · per 10mg
| Vendor | Price | $ / mg | Updated | |
|---|---|---|---|---|
| Guru PeptidesBest $/mgCOA unknown | $27.99 | $5.60 | May 16, 2026 | Buy → |
| Pinnacle Peptide LabsCOA on request | $33.99 | $6.80 | Apr 23, 2026 | Buy → |
| Modern AminosCOA ✓ · 3P | $88.00 | $8.80 | May 14, 2026 | Buy → |
| Core PeptidesCOA ✓ · 3P | $47.00 | $9.40 | Apr 16, 2026 | Buy → |
| Biotech PeptidesCOA unknown | $49.00 | $9.80 | May 14, 2026 | Buy → |
Overview
About Hexarelin
Mechanism of action
Potent synthetic GHRP-6 analogue; binds GHS-R1a (ghrelin receptor); strongest GH-releasing peptide per mcg; also has direct cardiac protective effects via CD36 receptor.
Safety profile
Significant cortisol and prolactin elevation (more than other GHRPs); water retention; increased appetite; desensitization with prolonged use; fatigue. · Human clinical data; more cortisol/prolactin than ipamorelin; cardiac effects studied; tolerable
Storage
Stability & handling
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Research
Studies & key findings
- Hexarelin is the most potent synthetic GHRP hexapeptide — Imbimbo et al. (Eur J Clin Pharmacol 1994) established a dose-response with GH peak concentrations of 3.9, 26.9, 52.3, and 55.0 ng/mL at escalating IV doses, with an ED50 of 0.5–0.64 µg/kg, while Ghigo et al. (JCEM 1994) showed hexarelin 2 µg/kg IV produced GH responses ~2-fold greater than maximal GHRH stimulation.
- Hexarelin exerts growth hormone-independent cardioprotective effects through dual receptor action: CD36 scavenger receptor binding (Bodart et al., Circ Res 2002) mediates direct cardiac cell protection, while Locatelli et al. (Endocrinology 1999) confirmed these effects persist in hypophysectomized rats — demonstrating a cardiac receptor mechanism fully separate from pituitary GH secretion.