DifelikefalinImmuneSafety Rating 8/10
Primary research areaModerate-to-severe CKD-associated pruritus in hemodialysis patients
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Research dose range0.5 mcg/kg IV at end of each dialysis session
AdministrationIntravenous
Safety8/10 · FDA-approved (Korsuva)
NCAA D1Not listed
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Overview
About Difelikefalin
Mechanism of action
Selective peripherally restricted kappa opioid receptor agonist; reduces itch signaling
Safety profile
Dizziness, nausea, somnolence, falls · Approved for CKD pruritus; no classic opioid abuse potential; dizziness, diarrhea
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