CJC-1295 (With DAC) research

The CJC-1295 evidence base cited here is 6 sources — 3 clinical, 2 preclinical. Its strongest evidence is human — 3 clinical studies, most recently 2009 ("Activation of the GH/IGF-1 Axis by CJC-1295 Results in Serum Protein Pro…"). Regulatory status: Not FDA-approved.

• The trade-off: it produces continuous GH/IGF-1 elevation rather than natural pulses, which is convenient but diverges from physiological secretion and carries a higher desensitization and side-effect profile.
• It is not FDA-approved and is sold for laboratory research only.

It is investigational, not FDA-approved, and everything below is research context rather than medical guidance.

It shares the same modified GHRH(1-29) core as the non-DAC version (30 amino acids), with an added Drug Affinity Complex — a maleimide group that covalently binds to albumin in the bloodstream. That albumin tethering is what extends the half-life to ~6–8 days (~120 hours), versus ~30 minutes for the non-DAC form. By mass it is ~3,647 Da.

The result is a steady, prolonged GHRH-receptor signal rather than discrete pulses — the central design difference, and the source of both its convenience and its drawbacks.

Like all GHRH analogs it binds pituitary GHRH receptors to stimulate GH release. But because the DAC keeps it in circulation for days, the receptor stimulation is continuous rather than pulsatile. Sustained signaling raises baseline GH/IGF-1, but animal data show it can also blunt GH pulse amplitude over time (partial desensitization) — the physiological cost of trading pulses for steady state.

• Teichman et al. (2006) — established the long (~multi-day) half-life conferred by the DAC.
• Comparative PK, DAC vs non-DAC (human crossover): ~120-hour half-life with DAC vs ~30 minutes without; the non-DAC form preserved more physiological GH patterns.
• Long-term GH/IGF-1 axis (animal, weekly, 6 months): sustained IGF-1 elevation but reduced GH pulse amplitude (partial desensitization).

Not FDA-approved for any use; sold as a research chemical for laboratory use only, not intended for human consumption. GH-axis peptides may also fall under sport anti-doping prohibitions — tested athletes should verify with their governing body.

All citations link to the original source (PubMed, journal site, or regulatory filing). Independent research database — no vendor influence on what's cited.