SS-31 (Elamipretide)Mitochondrial PeptideSafety Rating 8/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
Compare vendors · per 50mg
| Vendor | Price | $ / mg | Updated | |
|---|---|---|---|---|
| Petratide ScienceBest $/mgCOA ✓ · 3P | $99.95 | $2.00 | May 14, 2026 | Buy → |
| Puratek PeptidesCOA ✓ · 3POut of stock | $67.45 | $2.25 | May 19, 2026 | Buy → |
| PeptiraCOA ✓ · 3P | $139.00 | $2.78 | May 14, 2026 | Buy → |
| Evolve PeptidesCOA ✓ · 3P | $144.41 | $2.89 | Apr 22, 2026 | Buy → |
| Ascension PeptidesCOA ✓ · 3P | $37.50 | $3.75 | Apr 16, 2026 | Buy → |
Overview
About SS-31
Mechanism of action
Mitochondria-targeted antioxidant tetrapeptide; localizes to inner mitochondrial membrane; interacts with cardiolipin; reduces ROS; improves mitochondrial electron transport efficiency and ATP production.
Safety profile
Injection site reactions (pain, bruising). Generally well-tolerated in trials. Nausea reported. Long-term human data still emerging. · FDA-approved Sept 2025; 600+ patients in trials; injection site reactions main AE; well-tolerated
Storage
Stability & handling
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Research
Studies & key findings
- SS-31 selectively binds cardiolipin on the inner mitochondrial membrane, stabilizing cristae architecture and electron transport chain supercomplexes; PNAS proteomics identified 12 direct SS-31 interactors — all cardiolipin-binding proteins involved in OXPHOS and 2-oxoglutarate metabolism.
- Ex vivo treatment of explanted failing human hearts acutely improved mitochondrial respiration and supercomplex function, demonstrating the mechanism is independent of long-term cardiolipin remodeling (JACC: Basic to Translational Science, 2019).