PT-141 (Bremelanotide)Melanocortin PeptideSafety Rating 8/10

TypeCyclic heptapeptide
CAS189691-06-3
MW1,025.2 g/mol
AAs7
Primary research areaMelanocortin / sexual research

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose range0.5–2 mg SC 45–60 min before sexual activity. Start at 0.5–1 mg to assess tolerance. Max 1x/72 hours.
AdministrationInjection
Safety8/10 · FDA-approved (Vyleesi)
NCAA D1Not listed

Price Comparison

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Overview

About PT-141

Mechanism of action

Melanocortin receptor agonist (MC3R, MC4R). Acts centrally in the hypothalamus to stimulate sexual arousal independent of the vascular system. Does not affect blood pressure like PDE5 inhibitors.

Safety profile

Nausea (most common), flushing, headache, transient blood pressure increase, spontaneous erections, hyperpigmentation with repeated use. · FDA-approved for HSDD; nausea common (40%); transient BP increase; limited to 1 dose/24hr

Storage

Stability & handling

❄️Lyophilized (powder)2–8°Cprotect from light
💉Reconstituted2–8°Cwithin 30 days
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Safety & Interactions

Contraindications & Drug Interactions

Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.

⚠ CriticalContraindication

Uncontrolled hypertension.

⚠ CriticalContraindication

Known cardiovascular disease.

! CautionCaution

Transient BP increase (~6 mmHg SBP, ~3 mmHg DBP) lasting ~8 hours after each dose. Avoid in patients with CV risk factors.

Sources: FDA

Related pages

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Research

Studies & key findings

  • FDA-approved (Vyleesi, 2019) for hypoactive sexual desire disorder (HSDD) in premenopausal women — the first centrally-acting pharmacological treatment for female sexual dysfunction.
  • Two identical Phase 3 RCTs confirmed statistically and clinically significant increases in satisfying sexual events and decreases in distress scores vs placebo.

7 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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