Melanotan-2 (MT-2)Melanocortin PeptideSafety Rating 3/10
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Price Comparison
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| Vendor | Price | $ / mg | Updated | |
|---|---|---|---|---|
| Ascension PeptidesBest $/mgCOA ✓ · 3P | $20.00 | $2.00 | Apr 16, 2026 | Buy → |
| Amino ClubCOA ✓ · 3P | $23.99 | $2.40 | May 14, 2026 | Buy → |
| Axiom PeptidesCOA on request | $25.00 | $2.50 | Apr 14, 2026 | Buy → |
| Puratek PeptidesCOA ✓ · 3P | $25.16 | $2.52 | May 19, 2026 | Buy → |
| Red River PeptidesCOA ✓ · 3PAvailable on backorder | $25.50 | $2.55 | May 19, 2026 | Buy → |
Overview
About Melanotan-2
Mechanism of action
Non-selective melanocortin agonist (MC1R, MC3R, MC4R); stimulates melanin production; activates MC4R for potent sexual arousal; significantly more sexual effect than MT-1.
Safety profile
Nausea, facial flushing, fatigue, spontaneous erections, increased libido, yawning, hyperpigmentation, mole changes (monitor), potential cancer promotion concerns. · Documented serious harms: peer-reviewed melanoma/eruptive-nevi case reports with formal MHRA and TGA safety warnings, plus priapism (a urological emergency). Directly stimulates melanocytes. Nausea and flushing are common.
Storage
Stability & handling
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Safety & Interactions
Contraindications & Drug Interactions
Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.
Personal or family history of melanoma or atypical nevi — melanocortin agonists darken moles; theoretical melanoma risk debated but unproven.
Priapism (prolonged painful erection) — reported in literature. Emergency medical evaluation required if erection lasts >4 hours.
Rhabdomyolysis — case reports of muscle breakdown with high doses.
Related pages
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Frequently Researched Together
Research
Studies & key findings
- Synthetic cyclic α-MSH analog that binds MC1R, MC3R, MC4R and MC5R — the broad receptor profile is what drives both the tanning response (MC1R → tyrosinase → eumelanin) and the central pro-erectile/anorexic effects (MC4R in the hypothalamus), and is also why side effects cluster across so many systems.
- Originally developed at the University of Arizona in the 1980s for UV-sparing skin photoprotection in patients at high melanoma risk; Dorr et al. 1996 (Life Sciences) showed dose-dependent tanning in a Phase I trial, and Wessells 1998 (J Urology) demonstrated improved erections in men with psychogenic erectile dysfunction.