Melanotan I (afamelanotide) is a synthetic α-MSH analog that is SELECTIVE for the MC1 receptor, so it mainly does pigmentation/photoprotection, without the libido and appetite effects of the non-selective MT-II.
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Tracked every day
Melanotan-1 listing prices, tracked daily
The five cheapest in-stock package prices for Melanotan-1 on each collected day, and the vendors that most often held those places.
Five cheapest in-stock package prices per day
Listed package price before coupons, any vial size. This is not the coupon-adjusted lowest 10mg price used to rank the comparison.
- Cheapest$18.99
- 2nd cheapest$25.00
- 3rd cheapest$25.00
- 4th cheapest$25.00
- 5th cheapest$25.49
Vendors most often in the cheapest five
- T-Core Biotech21 days$26.99last seen Oct 9, 20260.0%
- Puratek Peptides16 days$27.95last seen Oct 5, 20260.0%
- Modern Research Peptides12 days$27.99last seen Oct 7, 20260.0%
- ZC Labs11 days$18.990.0%
- Rocky Mountain Compounds8 days$24.30last seen Oct 1, 20260.0%
- TrustedPeps7 days$25.00+25.0%
- Real Peptides6 days$28.80last seen Oct 6, 20260.0%
- American Amino & Peptides4 days$25.000.0%
Top 8 of 16 vendors that reached the cheapest five
Current market data
Melanotan-1 Price Report
A current summary of public listings after the price comparison above. Shipping and tax are not included.
The lowest current 10mg cost for Melanotan-1 is $18.04 from ZC Labs. The median across vendors is $34.82.
- Lowest 10mg cost
- $18.04ZC Labs
- Median 10mg cost
- $34.82One normalized offer per vendor
- Lowest package total
- $18.04ZC Labs · package size may differ
- Public COA coverage
- 99%85 of 86 vendors
What the market shows
PeptidePrices found 86 in-stock listings from 86 vendors, checked through Oct 10, 2026. The lowest 10mg cost is 48% below the vendor median of $34.82; 43 vendors (50%) fall below that median. 85 of 86 vendors (99%) publish public COA evidence.
A public COA link shows that a vendor publishes testing data. It does not prove that every listed vial has a matching current report. Match the product, strength, batch, and lot before relying on a report.
How this report is calculated
The headline and median use each vendor's lowest whole-package checkout cost to obtain at least 10mg. Smaller packages are multiplied until the target is met, while larger packages retain their full checkout price. The lowest package total is shown only as secondary context because package sizes differ. Known public coupon discounts are applied. Shipping, tax, and unverified promotions are excluded.
Research context
What is Melanotan-1? Research, safety, and status
Melanotan I (afamelanotide) stimulates the body's own melanin production by selectively activating the MC1 receptor on melanocytes. That selectivity is its defining trait: it's the 'cleaner' melanotan, focused on tanning and photoprotection rather than the multi-system effects of MT-II.
Key research takeaways
The defining safety practice for the tanning-peptide class: regular mole/skin self-monitoring, and keep using UV protection despite the enhanced tan.
Melanotan-1 at a glance
PeptidePrices safety rating
8/10 · FDA-approved (Scenesse)
Mechanism
Non-selective melanocortin receptor agonist (MC1R preference); stimulates eumelanin production in melanocytes; photoprotective; FDA-approved for erythropoietic protoporphyria (EPP).
Research areas
Skin tanning and photoprotection; erythropoietic protoporphyria (FDA-approved); vitiligo; skin pigmentation disorders.
Regulatory / research status
FDA approved (for specific indications)
Half-life
~30 minutes (SC).
Storage
Lyophilized vial: store at -20°C long-term or 2-8°C short-term, protected from light.
Reported side effects
Nausea, facial flushing, fatigue, spontaneous erections. Less sexual side effects than MT-2. Hyperpigmentation, mole changes.
FDA/EMA approved for EPP; nausea, headache mild; selective MC1R agonist; well-studied Safety ratings summarize published clinical data, adverse-event reporting, and regulatory status. How PeptidePrices rates evidence. Research information only, not medical advice.
Study highlights
- FDA-approved as afamelanotide (Scenesse) for erythropoietic protoporphyria (EPP), the first melanocortin agonist to receive regulatory approval anywhere in the world.
- NEJM Phase 3 RCT (2015) demonstrated a significant increase in pain-free time in sunlight (duration doubled vs placebo) in EPP patients.
- Under investigation for vitiligo (afamelanotide + NB-UVB combination), polymorphic light eruption, and other photodermatoses with UV-sensitivity.
Selected references
- Afamelanotide for Erythropoietic Protoporphyria, Phase 3 RCT · New England Journal of Medicine, 2015
- Pharmacokinetics, Pharmacodynamics, and Clinical Use of Afamelanotide · Clinical Pharmacokinetics, 2017
- Afamelanotide for Broad Dermatologic Applications · Journal of Drugs in Dermatology, 2021
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