Melanocortin Peptide
Melanotan-1
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Research details
Melanotan-1 — research data
Half-life~30 minutes (SC). Pulsatile dosing every other day.
Regulatory statusFDA-approved (Scenesse)
NCAA D1Not listed
Overview
About Melanotan-1
Mechanism of action
Non-selective melanocortin receptor agonist (MC1R preference); stimulates eumelanin production in melanocytes; photoprotective; FDA-approved for erythropoietic protoporphyria (EPP).
Safety profile
Nausea, facial flushing, fatigue, spontaneous erections. Less sexual side effects than MT-2. Hyperpigmentation, mole changes. · FDA/EMA approved for EPP; nausea, headache mild; selective MC1R agonist; well-studied
Storage
Stability & handling
Lyophilized (powder)2–8°Cstable for years
Reconstituted2–8°Cwithin 30 days
Related pages
More on Melanotan-1
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Research
Studies & key findings
- FDA-approved as afamelanotide (Scenesse) for erythropoietic protoporphyria (EPP) — the first melanocortin agonist to receive regulatory approval anywhere in the world.
- NEJM Phase 3 RCT (2015) demonstrated a significant increase in pain-free time in sunlight (duration doubled vs placebo) in EPP patients.