Matrixyl (Palmitoyl Pentapeptide-4)Cosmetic PeptideSafety Rating 9/10
TypePalmitoylated pentapeptide
CAS214047-00-4
MW802.05 g/mol
AAs5 (palmitoylated)
Primary research areaSkin / collagen research
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Research dose rangeTopical: 2–8% concentration in serums. Apply 1–2x/day to face and neck.
AdministrationTopical
Safety9/10 · Cosmetic use (topical)
NCAA D1Not listed
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Overview
About Matrixyl
Mechanism of action
Lipopeptide that mimics a fragment of collagen; binds TGF-β receptors; stimulates synthesis of collagen I, III, fibronectin, and hyaluronic acid in dermal fibroblasts.
Safety profile
Very safe topically. Rare mild irritation. No systemic effects. · Thousands of skincare products; extensive safety data; topical only; extremely well-tolerated
Storage
Stability & handling
Lyophilized (powder)−20°Clong-term stable
Reconstituted2–8°Cwithin 30 days
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Research
Studies & key findings
- Palmitoyl-KTTKS (Pal-KTTKS) functions as a matrikine — a collagen-derived signaling fragment that activates TGF-β receptors on dermal fibroblasts, stimulating dose-dependent synthesis of collagen types I, III, and IV, fibronectin, and glucosaminoglycans without the irritation profile of retinoids.
- A 12-week, double-blind, placebo-controlled split-face study in 93 women found 3 ppm Pal-KTTKS in moisturizer produced significant improvements in wrinkle depth and fine lines versus placebo on both quantitative imaging and expert grader assessment.