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Matrixyl

Cosmetic Peptide

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VendorPrice10mg costUpdatedActions
CertaPeptides7.5/10
7.5/10
COA ✓Ships: InternationalPayment not verified
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7.5/10
COA ✓Ships: InternationalPayment not verified
$14.8010mg package$14.80Checked jun 27, 2026Jun 27, 2026Buy Matrixyl from CertaPeptides

Research details

Matrixyl — research data

Half-lifeTopical penetration-dependent. No injection protocol.
Regulatory statusCosmetic use (topical)
NCAA D1Not listed

Overview

About Matrixyl

Mechanism of action

Lipopeptide that mimics a fragment of collagen; binds TGF-β receptors; stimulates synthesis of collagen I, III, fibronectin, and hyaluronic acid in dermal fibroblasts.

Safety profile

Very safe topically. Rare mild irritation. No systemic effects. · Thousands of skincare products; extensive safety data; topical only; extremely well-tolerated

Storage

Stability & handling

❄️Lyophilized (powder)−20°Clong-term stable
💉Reconstituted2–8°Cwithin 30 days

Related pages

More on Matrixyl

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Research

Studies & key findings

  • Palmitoyl-KTTKS (Pal-KTTKS) functions as a matrikine — a collagen-derived signaling fragment that activates TGF-β receptors on dermal fibroblasts, stimulating dose-dependent synthesis of collagen types I, III, and IV, fibronectin, and glucosaminoglycans without the irritation profile of retinoids.
  • A 12-week, double-blind, placebo-controlled split-face study in 93 women found 3 ppm Pal-KTTKS in moisturizer produced significant improvements in wrinkle depth and fine lines versus placebo on both quantitative imaging and expert grader assessment.

6 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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