Kisspeptin-10LibidoSafety Rating 7/10

Primary research areaTestosterone and LH optimization

Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.

Research dose range100–500 mcg SC once or twice daily. Some pulse protocols mimic LH surges. Cycle 4–8 weeks.
AdministrationVaries
Safety7/10 · Not FDA-approved (research)
NCAA D1Banned

Price Comparison

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Overview

About Kisspeptin-10

Mechanism of action

Endogenous neuropeptide; binds KISS1R (GPR54); potent stimulator of GnRH release, driving LH and FSH surges; key regulator of reproductive axis; also inhibits cancer metastasis.

Safety profile

Injection site reactions; potential LH/FSH overstimulation. Generally well-tolerated. Long-term data limited. · Multiple human clinical studies; well-tolerated; short-acting; no serious adverse events

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Related pages

More on Kisspeptin-10

Research

Studies & key findings

  • Kisspeptin-10, the shortest bioactive form of kisspeptin (a GPR54/KISS1R ligand), robustly stimulates LH pulse frequency in healthy men at all tested IV doses; a continuous infusion of 1.5 µg/kg/h increased LH pulse frequency and significantly elevated testosterone, identifying its therapeutic potential as an LH/testosterone axis modulator.
  • Responsiveness to kisspeptin-10 shows pronounced sexual dimorphism: robust LH/FSH release occurs in men at all cycle phases and in women only during the preovulatory phase — not during the follicular phase — indicating cycle-phase sensitivity must be accounted for in reproductive disorder treatment protocols.

7 peer-reviewed sources cited — clinical, preclinical, and regulatory.

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