HCG (Human Chorionic Gonadotropin) Price Comparison — Compare 4 Vendors
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Research details
HCG — research data
Research-literature reference data, NOT patient instructions. Not for human use. Consult a licensed clinician for any human application.
Overview
About HCG
Mechanism of action
Glycoprotein hormone; mimics LH; binds LH receptors on Leydig cells; stimulates testosterone production; maintains testicular size and fertility during TRT; stimulates ovulation in females.
Safety profile
Gynecomastia risk (aromatization of testosterone), testicular pain, headache, mood swings, water retention, desensitization of Leydig cells with high-dose continuous use. · Decades of use; OHSS risk in women; headache; very well-characterized
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Research
Studies & key findings
- hCG, a glycoprotein hormone with full LH-receptor agonism, has been FDA-approved since 1939 for cryptorchidism and hypogonadotropic hypogonadism; it stimulates Leydig cell testosterone synthesis and seminiferous tubule spermatogenesis, serving as the pharmacological substitute for LH in men with secondary hypogonadal infertility.
- A randomized double-blind study showed that adding low-dose hCG (250–500 IU every other day) to testosterone replacement therapy limits the decline in intratesticular testosterone to only 7% (vs. 94% decline with TRT alone) and prevents the azoospermia that typically develops within 10 weeks of TRT — the principal clinical use case for hCG co-administration.