Price Comparison
FOXO4-DRI
| Vendor | Price | 10mg cost | Updated | Actions |
|---|---|---|---|---|
| Alpha Peptides 8/10 COA ✓Ships: USCredit/debit card Verification & shipping8/10 COA ✓Ships: USCredit/debit card | $62.63 | $62.63Checked jul 31, 2026 | Jul 31, 2026 | Buy FOXO4-DRI from Alpha Peptides |
| Ascension Peptides 8.5/10 COA ✓Ships: USVisa · ACH bank draft Verification & shipping8.5/10 COA ✓Ships: USVisa · ACH bank draft | $100.00 | $100.00Checked apr 16, 2026 | Apr 16, 2026 | Buy FOXO4-DRI from Ascension Peptides |
| MS Peptides 8/10 COA ✓Ships: US + internationalCredit/debit card · ACH Verification & shipping8/10 COA ✓Ships: US + internationalCredit/debit card · ACH | $116.96 | $116.96Checked aug 19, 2026 | Aug 19, 2026 | Buy FOXO4-DRI from MS Peptides |
| Glacier Aminos 8.5/10 COA ✓Ships: USCredit/debit card Verification & shipping8.5/10 COA ✓Ships: USCredit/debit card | $121.49 | $121.49Checked jul 31, 2026 | Jul 31, 2026 | Buy FOXO4-DRI from Glacier Aminos |
| Atomik Labz 7/10 COA ✓Ships: US + CanadaPayment not verified Verification & shipping7/10 COA ✓Ships: US + CanadaPayment not verified | $149.25 | $149.25Checked aug 4, 2026 | Aug 4, 2026 | Buy FOXO4-DRI from Atomik Labz |
| Offline Peptides 7.5/10 COA ✓Ships: USCredit/debit card Verification & shipping7.5/10 COA ✓Ships: USCredit/debit card | $159.0010mg package | $159.00Checked jul 28, 2026 | Jul 28, 2026 | Buy FOXO4-DRI from Offline Peptides |
Research details
FOXO4-DRI — research data
Overview
About FOXO4-DRI
Mechanism of action
D-amino acid retro-inverso FOXO4 peptide; disrupts FOXO4-p53 interaction in senescent cells; triggers selective apoptosis of senescent cells (senolytic); clears 'zombie cells' without harming normal cells.
Safety profile
Potential weight loss, lethargy in animal models. Long-term human data very limited. Theoretical risk: removal of beneficial senescent cells in wound healing. · Experimental senolytic that works by disrupting the FOXO4–p53 interaction. p53 is the master tumor-suppressor protein — modulating it carries serious theoretical oncogenic risk, and there is zero human safety data. Animal data only.
Storage
Stability & handling
Safety & Interactions
Contraindications & Drug Interactions
Research use only — not medical advice. Consult a licensed physician before using any peptide. Sources are cited where available.
Experimental senolytic with limited human data. Selectively targets senescent cells in animal studies.
Related pages
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Research
Studies & key findings
- FOXO4-DRI is a D-amino acid retro-inverso peptide that disrupts the interaction between FOXO4 and p53 in senescent cells; in normal senescent cells FOXO4 sequesters p53 in nuclear PML bodies, preventing its pro-apoptotic function — FOXO4-DRI competitively displaces this interaction, causing p53 nuclear exclusion and activation of apoptosis selectively in senescent cells.
- The landmark 2017 Cell paper demonstrated that FOXO4-DRI restored fitness, fur density, and renal function in both fast-aging XpdTTD/TTD mice and naturally aged mice, and reduced doxorubicin-induced chemotoxicity in a senescence-dependent manner — providing the first in vivo proof that selective senescent cell elimination with a peptide reverses multiple aging-associated phenotypes.