Price Comparison
Dihexa
| Vendor | Price | 10mg cost | Updated | Actions |
|---|---|---|---|---|
| Elytra Labs 7.5/10 COA ✓Ships: USCredit/debit card Verification & shipping7.5/10 COA ✓Ships: USCredit/debit card | $38.00 | $38.00Checked aug 2, 2026 | Aug 2, 2026 | Buy Dihexa from Elytra Labs |
| Pristine Aminos 4.5/10 COA on requestShips: USCredit/debit card Verification & shipping4.5/10 COA on requestShips: USCredit/debit card | $65.0010mg package | $65.00Checked aug 2, 2026 | Aug 2, 2026 | Buy Dihexa from Pristine Aminos |
| Alpha Peptides 8/10 COA ✓Ships: USCredit/debit card Verification & shipping8/10 COA ✓Ships: USCredit/debit card | $35.79 | $71.58Checked jul 31, 2026 | Jul 31, 2026 | Buy Dihexa from Alpha Peptides |
| NeuroLabs 8.5/10 COA ✓Ships: US + internationalVisa · Mastercard Verification & shipping8.5/10 COA ✓Ships: US + internationalVisa · Mastercard | $74.9510mg package | $74.95Checked jul 31, 2026 | Jul 31, 2026 | Buy Dihexa from NeuroLabs |
| VoidResearch 7/10 COA ✓Ships: WorldwideCryptocurrency · Zelle Verification & shipping7/10 COA ✓Ships: WorldwideCryptocurrency · Zelle | $76.50 | $76.50Checked jul 30, 2026 | Jul 30, 2026 | Buy Dihexa from VoidResearch |
| Licensed Peptides 8/10 COA ✓Ships: US + internationalCredit/debit card Verification & shipping8/10 COA ✓Ships: US + internationalCredit/debit card | $129.995% off via our link·auto10mg package | $129.99Checked jun 4, 2026 | Jun 4, 2026 | Buy Dihexa from Licensed Peptides |
Research details
Dihexa — research data
Overview
About Dihexa
Mechanism of action
HGF/MET system potentiator; derived from angiotensin IV; binds hepatocyte growth factor (HGF) and prevents its degradation; activates MET receptor; promotes synaptogenesis, dendritic spine density, and neuroplasticity; ~7 orders of magnitude more potent than BDNF per unit.
Safety profile
Limited human data. Potential: overstimulation, anxiety, insomnia at high doses. Theoretical cancer concern (HGF/MET pathway implicated in tumor growth — use with caution in cancer history). · Acts via c-Met activation — a tumor-growth pathway — giving a real oncogenicity concern; no long-term or human safety data; no human trials. Generally avoided with any cancer history.
Storage
Stability & handling
Related pages
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Research
Studies & key findings
- Dihexa is an orally active, blood-brain-barrier-permeable angiotensin IV analogue that potentiates hepatocyte growth factor (HGF) signaling at the c-Met receptor; the original 2014 JPET paper (PMID 25187433) reported it induced hippocampal spinogenesis and synaptogenesis orders of magnitude more potently than BDNF — however, this paper was formally retracted in April 2025 (PMID 40312093) due to data integrity concerns, and its primary findings should not be cited as established.
- A 2021 Brain Sciences study independent of the retracted group found that Dihexa treatment improved spatial learning and memory in APP/PS1 Alzheimer's model mice, reduced neuroinflammatory markers, and restored neuronal populations; the beneficial effects were blocked by PI3K/AKT pathway inhibitors, identifying this axis as the operative downstream mechanism.