Side-by-side comparison
Semaglutide vs Retatrutide — Price & Profile Comparison
Semaglutide
GLP-1 PeptideSafety 8/10Metabolic / weight research
Retatrutide
Triple-Action Metabolic CompoundSafety 7/10GLP-1 / metabolic research
The short answer
Semaglutide vs Retatrutide: which to choose
Semaglutide is the cheaper option — roughly $13 vs $25 for the lowest verified listing. Retatrutide is the more widely stocked of the two (35 vendors vs 22). Semaglutide carries the higher safety rating (8/10 vs 7/10). They target different goals — Semaglutide is a glp-1 peptide compound while Retatrutide is a triple-action metabolic compound one — so they're often complementary rather than direct substitutes.
Price Comparison — 2026
Semaglutide
Retatrutide
Vendors Carrying Both
22 vendors stock both Semaglutide and Retatrutide — convenient if you want to bundle an order.
Safety Notes
Semaglutide
FDA: FDA-approved (Ozempic/Wegovy)
Extensive safety data; GI side effects common but manageable; cardiovascular benefit; thyroid warning animal-only
Retatrutide
FDA: Not FDA-approved (Phase III)
Phase II showed strong efficacy/tolerability; GI side effects; novel mechanism; promising safety data
Explore Further
Semaglutide
Retatrutide