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Other sizes and packages · 27 vendors

Semax listing prices

The blue line is the lowest in-stock package total each collected day; the band is the next four cheapest.

Method

Package totals before coupons and shipping. Strengths can differ between vendors and dates, so this is not a per-mg index. A day without a collection stays a gap.

31 collected days –

Lowest package price, with the next four cheapest as a bandLowest in-stock package total: 31 collected days, Sep 30, 2026 – Oct 30, 2026. The blue line is the lowest in-stock package total each collected day; the band is the next four cheapest.$10$20$30Sep 30, 2026: $19.95 lowest, $23.99 at the top of the fiveOct 1, 2026: $19.95 lowest, $24.99 at the top of the fiveOct 2, 2026: $19.95 lowest, $24.99 at the top of the fiveOct 3, 2026: $19.95 lowest, $25.00 at the top of the fiveOct 4, 2026: $19.95 lowest, $25.00 at the top of the fiveOct 5, 2026: $19.95 lowest, $25.00 at the top of the fiveOct 6, 2026: $19.95 lowest, $24.99 at the top of the fiveOct 7, 2026: $19.95 lowest, $24.99 at the top of the fiveOct 8, 2026: $18.49 lowest, $23.99 at the top of the fiveOct 9, 2026: $18.49 lowest, $23.99 at the top of the fiveOct 10, 2026: $18.49 lowest, $21.99 at the top of the fiveOct 11, 2026: $18.49 lowest, $21.99 at the top of the fiveOct 12, 2026: $18.49 lowest, $21.99 at the top of the fiveOct 13, 2026: $11.95 lowest, $20.80 at the top of the fiveOct 14, 2026: $11.95 lowest, $19.99 at the top of the fiveOct 15, 2026: $11.95 lowest, $21.99 at the top of the fiveOct 16, 2026: $11.95 lowest, $21.99 at the top of the fiveOct 17, 2026: $11.95 lowest, $24.79 at the top of the fiveOct 18, 2026: $11.95 lowest, $24.59 at the top of the fiveOct 19, 2026: $11.95 lowest, $23.69 at the top of the fiveOct 20, 2026: $11.95 lowest, $24.79 at the top of the fiveOct 21, 2026: $11.95 lowest, $24.99 at the top of the fiveOct 22, 2026: $11.95 lowest, $23.69 at the top of the fiveOct 23, 2026: $11.95 lowest, $24.79 at the top of the fiveOct 24, 2026: $11.95 lowest, $24.79 at the top of the fiveOct 25, 2026: $18.58 lowest, $22.44 at the top of the fiveOct 26, 2026: $18.58 lowest, $21.99 at the top of the fiveOct 27, 2026: $18.19 lowest, $21.99 at the top of the fiveOct 28, 2026: $15.39 lowest, $21.99 at the top of the fiveOct 29, 2026: $15.39 lowest, $21.00 at the top of the fiveOct 30, 2026: $15.39 lowest, $21.00 at the top of the five$15.39$21.00Sep 30, 2026Oct 10, 2026Oct 20, 2026Oct 30, 2026
Latest $15.39$18.59$19.99$20.99$21.00

Before coupons (table prices apply them), the lowest Semax package price moved from $19.95 on Sep 30, 2026 to $15.39 on Oct 30, 2026; 19 vendors reached the cheapest five.

Vendors in the cheapest five

8 / 19
Vendors that appeared in the five cheapest listings, with collected days and the last top-five package price.
VendorDays in fiveLast top-five package
Pro Research Peptide 31$19.99
Modern Research Peptides 27$21.99
ORA Labs 25$11.95 -40.1%
OneDay Compounds 9$20.99 -7.7%
Solus Peptide Labs 8$18.59 +2.0%
Corix Labs 8$22.44 +21.4%
IDUN Peptides 8$24.99
PeakForce Labs 6$20.80

Top 8 of 19 vendors that reached the cheapest five

Current market data

Semax Price Report

How this report is calculated

The headline and median use each vendor's lowest whole-package checkout cost to obtain at least 10mg. Smaller packages are multiplied until the target is met, while larger packages retain their full checkout price. The lowest package total is shown only as secondary context because package sizes differ. Known public coupon discounts are applied. Shipping, tax, and unverified promotions are excluded. COA coverage counts vendors with an exact compound-and-strength match in the listing-evidence projection; report dates and lot identifiers remain specific to each certificate.

Compare current Semax prices and matching laboratory evidence.

Checked through

The lowest current 10mg cost for Semax is $15.39 from Arkon Labs Research. The median across vendors is $38.25.

Lowest 10mg cost
$15.39Arkon Labs Research
Median 10mg cost
$38.25One normalized offer per vendor
Lowest package total
$9.56ORA Labs · package size may differ
Vendors with matching verified COAs
127of 205 vendors · Semax

What the market shows

PeptidePrices found 238 in-stock listings from 205 vendors, checked through Oct 30, 2026. The lowest 10mg cost is 60% below the vendor median of $38.25; 102 vendors (50%) fall below that median. 127 of 205 vendors (62%) have an exact issuer-verified COA for at least one listed Semax strength.

Open the Peptide Market IndexCompare two compoundsRead the calculation notes

Research and literature

Semax: The Synthetic ACTH Fragment Studied for Stroke Recovery and Neurotrophin Signaling

Updated  · Written by and

Semax is a synthetic seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro): the ACTH(4-7) fragment extended with a C-terminal Pro-Gly-Pro tail [4]. It is a registered nasal-drop medicine in Russia, where most of its clinical research was conducted, but it is not an FDA-approved drug [5].

Human studies are concentrated in post-stroke rehabilitation and motor neuron disease; independent, adequately powered trials of cognitive enhancement in healthy adults are not available [1][2]. The catalog's N-Acetyl Semax Amidate and Semax Spray entries are separate products, and their evidence should not be merged with the parent peptide.

Key takeaways

  • In a 110-patient post-stroke rehabilitation study, adding Semax to standard rehabilitation raised plasma BDNF and was associated with faster motor and Barthel-index improvement; the accessible report does not describe randomization or blinding [1].
  • In a 27-patient open-label motor neuron disease study, Semax did not alter denervation or clinical progression, but it improved the emotional and motivational components of a quality-of-life scale [2].
  • Rodent work supports a neurotrophin-mediated mechanism: a single dose increased hippocampal BDNF protein and trkB signaling, and ischemic-rat studies show lower inflammatory and cell-death markers [3][4].

How it works

Neurotrophin signaling through BDNF and trkB

Semax combines the ACTH(4-7) sequence with a C-terminal Pro-Gly-Pro tail [4]. The best-supported laboratory mechanism is neurotrophin signaling: in rats, a single intranasal dose produced a 1.4-fold rise in hippocampal BDNF protein, a 1.6-fold rise in phosphorylated trkB, and larger increases in BDNF exon III and trkB mRNA, alongside more conditioned avoidance responses [3]. Separate rat work found rapid, region-specific changes in NGF and BDNF expression rather than a uniform increase [6].

Protective signaling after ischemia

In a transient middle-cerebral-artery-occlusion model, Semax increased active CREB and reduced MMP-9, c-Fos, and active JNK in ischemic and adjacent tissue [4]. These are biomarker and signaling findings, not proof that the same changes produce cognitive benefit in people.

What has been studied in humans

The largest accessible human study enrolled 110 adults after ischemic stroke (43 men, 67 women; mean age 58) and compared Semax-treated and untreated subgroups within early and late rehabilitation cohorts [1]. Two 10-day courses separated by 20 days raised plasma BDNF for the whole study period and were associated with faster functional recovery and a better final Barthel index; early rehabilitation showed a similar association [1]. The abstract does not report randomization, placebo, or blinding, so the effect size is uncertain. A second study followed 27 patients with motor neuron disease in an open-label, sequential-group design: two 10-day intranasal courses did not change the course of chronic partial denervation or clinical rating scales, but the total quality-of-life score improved, driven by emotional state and motivation, with the largest change at day 10 [2]. No rigorous trial of Semax for cognitive enhancement in healthy adults was identified. The Russian registration covers a 0.1% nasal-drop medicine, not the acetylated amidate or spray products [5].

Doses studied in human trials

Regimens below are those reported in the cited human trials.

Ischaemic stroke rehabilitation

6,000 mcg/day (6 mg/day) for 10 days per course, with two courses separated by 20 days.

110 adults after ischemic stroke (43 men, 67 women; mean age 58)

Motor neuron disease, open-label

1% solution, 12 mg/day intranasally, in two 10-day courses separated by 2 weeks.

27 patients with definite, probable, or possible motor neuron disease

Lab and animal studies

In male Wistar rats, a single Semax dose increased hippocampal BDNF protein and trkB phosphorylation and raised BDNF and trkB mRNA, with a parallel increase in conditioned avoidance reactions [3]. Time-course work in rats found that NGF and BDNF gene expression moved in different directions across hippocampus, frontal cortex, and retina, which argues against a simple global increase [6]. In rats subjected to transient middle cerebral artery occlusion, Semax increased active CREB in subcortical structures including the ischemic focus and reduced MMP-9 and c-Fos in adjacent cortex and active JNK in both tissues at 24 hours [4]. These studies establish plausible neurotrophic and anti-inflammatory activity in rodents; they do not establish a human cognitive endpoint.

Research in detail

The efficacy of Semax in the treatment of patients at different stages of ischemic stroke

Prospective controlled clinical study; Semax-treated and untreated subgroups within early and late rehabilitation cohorts; randomization and blinding not stated in the accessible abstract · 110 adults after ischemic stroke (43 men, 67 women; mean age 58)

Two 10-day courses separated by 20 days increased plasma BDNF, and Semax-treated patients showed faster improvement and better final Barthel scores; early rehabilitation was independently associated with better motor performance.

Evidence scope: Single-country study, no placebo arm described, allocation and blinding unclear, and BDNF was a surrogate rather than a cognitive endpoint.

The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with Semax

Open-label clinical trial in sequential groups; two 10-day intranasal courses separated by two weeks · 27 patients with definite, probable, or possible motor neuron disease

Semax did not change the course of chronic partial denervation or the dynamics of clinical functional scales, but it significantly improved total quality of life, mainly through emotional state and motivation, with the largest effect at day 10.

Evidence scope: Very small, open-label, no concurrent control, and the quality-of-life change was not blinded or adjusted for expectation.

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

Controlled rodent experiment with single peptide administration, protein and mRNA measurement, and a conditioned avoidance task · Rats

A single dose produced a maximal 1.4-fold increase in hippocampal BDNF protein, 1.6-fold increase in trkB tyrosine phosphorylation, and 3-fold and 2-fold increases in BDNF exon III and trkB mRNA; treated animals also showed more conditioned avoidance reactions.

Evidence scope: Rodent model with a short observation window; the behavioral task is not a human cognitive measure.

Brain protein expression profile confirms the protective effect of the ACTH(4-7)PGP peptide (Semax) in a rat model of cerebral ischemia-reperfusion

Rodent transient middle cerebral artery occlusion study with brain protein profiling at 24 hours · Rats

Semax increased active CREB in subcortical structures including the ischemic focus, reduced MMP-9 and c-Fos in adjacent frontoparietal cortex, and reduced active JNK in both tissues.

Evidence scope: Mechanistic protein profiling only; no long-term functional or cognitive outcome and no human translation.

The future: what's next for Semax

  • Whether the plasma BDNF rise seen after stroke is a mediator of recovery or a bystander marker, and whether it predicts benefit in a blinded trial [1].
  • Whether any cognitive effect exists in healthy adults, as opposed to recovery after injury, since the available human studies enrolled patients with stroke or motor neuron disease [1][2].
  • Whether acetylation, amidation, or spray formulation changes brain exposure, stability, or safety enough to require separate clinical data.

Price, research & COA

Quick answers about Semax

Price answers use the live price, vendor, and certificate data on this page. Research answers cite the numbered sources below.

What is the cheapest Semax listing?

Arkon Labs Research has the lowest 10mg listing at $15.39, checked October 30, 2026.

You can view the cheapest prices for other strengths and sizes in the table directly below.

Cheapest in-stock listing by strength
StrengthVendorPriceChecked
5mgORA Labs$9.56October 24, 2026
10mgArkon Labs Research$15.39October 30, 2026
20mgBioPoint Peptides$54.00October 18, 2026
30mgCapstone Peptides$39.50October 30, 2026
40mgEverest Peptides$50.99September 4, 2026
50mgTrulife Peptides$128.00October 30, 2026
100mgTrulife Peptides$232.00October 30, 2026

Prices apply known public coupon codes; shipping and tax are not included.

Compare current listings →

How much does Semax cost?

PeptidePrices currently compares 205 tracked vendors for Semax. The median 10mg price is $36.00, checked on October 30, 2026, from a sample of 178 vendors.

You can view the median cost for other strengths and sizes beneath.

Median in-stock price by strength
StrengthMedianVendorsPrice range
5mg$30.2134$9.56 to $49.50
10mg$36.00178$15.39 to $109.99
20mg$79.632$54.00 to $105.26
30mg$67.7516$39.50 to $157.88
40mgSingle listing1$50.99
50mg$162.602$128.00 to $197.20
100mgSingle listing1$232.00

Prices apply known public coupon codes; shipping and tax are not included.

Compare current listings →

Which Semax vendor is best?

No single vendor is best for every researcher. Compare Semax vendors on total cost, PeptidePrices quality rating, attached COA evidence, payment options, shipping, and how recently the listing was checked. We encourage researchers to read through our vendor reviews and inspect the attached COAs before making a decision. You can review our methodology here.

Should I pick a Semax vendor with a COA?

Yes. The PeptidePrices editorial team generally recommends that researchers only purchase from vendors with COAs attached to their Semax listing. If a vendor with a COA doesn't meet all of your buying needs, that's all right: Semax currently has 127 vendors with an in-stock listing that carries a matched COA. Without leaving this page, you can open each matched certificate PDF in the on-page viewer and see the issuing laboratory, report date and test panel. You can also read our independent analysis of purity, content, identity, endotoxin and the other panels, then follow the link to verify the certificate on the lab's own record.

Compare listings and their COAs →

How do I find the cheapest Semax for the size I want?

The comparison table lists all 205 tracked vendors for Semax, sorted by price. Use Size to compare one or more vial strengths, Ships to for the US, Canada, the UK, Australia, the EU or international destinations, and Payment method for credit or debit card, ACH or bank transfer, Zelle, Cash App, Venmo, PayPal, Apple Pay, cryptocurrency or Interac e-Transfer.

Open the comparison →

How can I check the COA on a Semax listing?

A vendor's certificate of analysis is attached to its listing when it matches the exact compound, strength and unit. 127 of the 205 vendors currently have an issuer-verified certificate attached. Open it to read the full certificate in an on-page viewer you can zoom, with our summary of the reported results beside it: purity, content and identity, plus endotoxin, sterility, heavy metals and fentanyl screens when the vendor had them tested. To check it yourself, follow the link to the laboratory's own verification record, where the laboratory publishes one, and to the original certificate on the vendor's site.

Open a listing's COA →

Has Semax been tested in humans?

Yes, in small studies of patients rather than healthy adults. A 110-patient post-stroke rehabilitation study linked Semax to a rise in plasma BDNF and faster motor and Barthel-index improvement, but the accessible report does not describe randomization or blinding [1]. A 27-patient open-label motor neuron disease study found no change in denervation or clinical progression, with improvement in the emotional and motivational parts of a quality-of-life scale [2]. No rigorous trial of Semax for cognitive enhancement in healthy adults has been identified.

Is Semax FDA approved?

No, Semax is not an FDA-approved drug. It is registered in Russia as a 0.1% nasal-drop medicine, and most of its clinical research was conducted there [5]. That registration covers the parent nasal drops, not the catalog's N-Acetyl Semax Amidate or Semax Spray products [5].

How does Semax work?

The best-supported laboratory mechanism is neurotrophin signaling. In rats, a single dose raised hippocampal BDNF protein and trkB phosphorylation, and separate rat work found region-specific shifts in NGF and BDNF expression [3][6]. In rats with a transient middle cerebral artery occlusion, an experimental stroke model, Semax increased active CREB and lowered MMP-9, c-Fos, and active JNK in ischemic and adjacent tissue [4]. These are rodent signaling findings, and it is not established that the same changes produce cognitive benefit in humans.

Sources

  1. The efficacy of Semax in the treatment of patients at different stages of ischemic strokeZhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova, 2018
  2. The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with SemaxZhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova, 2007
  3. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusBrain Research, 2006
  4. Brain protein expression profile confirms the protective effect of the ACTH(4-7)PGP peptide (Semax) in a rat model of cerebral ischemia-reperfusionInternational Journal of Molecular Sciences, 2021
  5. Semax 0.1% nasal drops, Russian marketing authorization LP-No.(009449)-(RG-RU)Russian State Register of Medicines (GRLS), via Vidal drug directory, 2025
  6. Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax actionJournal of Molecular Neuroscience, 2010

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